Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2678370..2679201 Replicon chromosome
Accession NZ_CP080118
Organism Escherichia coli strain M70

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag KZX75_RS12515 Protein ID WP_000854815.1
Coordinates 2678370..2678744 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag KZX75_RS12520 Protein ID WP_001280918.1
Coordinates 2678833..2679201 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX75_RS12475 (2673766) 2673766..2674932 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
KZX75_RS12480 (2675051) 2675051..2675524 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
KZX75_RS12485 (2675722) 2675722..2676780 + 1059 WP_001200889.1 FUSC family protein -
KZX75_RS12490 (2676952) 2676952..2677281 + 330 WP_000450409.1 DUF496 family protein -
KZX75_RS25205 (2677382) 2677382..2677705 - 324 WP_225469267.1 EutP/PduV family microcompartment system protein -
KZX75_RS25210 (2677684) 2677684..2677764 + 81 WP_023441679.1 hypothetical protein -
KZX75_RS12505 (2678053) 2678053..2678133 - 81 Protein_2451 hypothetical protein -
KZX75_RS12510 (2678179) 2678179..2678373 - 195 WP_000988600.1 DUF5983 family protein -
KZX75_RS12515 (2678370) 2678370..2678744 - 375 WP_000854815.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KZX75_RS12520 (2678833) 2678833..2679201 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZX75_RS12525 (2679217) 2679217..2679861 - 645 WP_000086752.1 hypothetical protein -
KZX75_RS12530 (2679880) 2679880..2680101 - 222 WP_000692345.1 DUF987 domain-containing protein -
KZX75_RS12535 (2680164) 2680164..2680640 - 477 WP_001186200.1 RadC family protein -
KZX75_RS12540 (2680656) 2680656..2681129 - 474 WP_001542276.1 antirestriction protein -
KZX75_RS12545 (2681223) 2681223..2681468 - 246 WP_001164966.1 hypothetical protein -
KZX75_RS12550 (2681468) 2681468..2682286 - 819 WP_001542275.1 DUF932 domain-containing protein -
KZX75_RS12555 (2682507) 2682507..2682917 - 411 WP_000846703.1 hypothetical protein -
KZX75_RS12560 (2682933) 2682933..2683283 - 351 Protein_2462 hypothetical protein -
KZX75_RS12565 (2683366) 2683366..2684112 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T210856 WP_000854815.1 NZ_CP080118:c2678744-2678370 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T210856 NZ_CP104639:1348062-1348526 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT210856 WP_001280918.1 NZ_CP080118:c2679201-2678833 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT210856 NZ_CP104639:1347727-1348062 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References