210852

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 1595839..1597120 Replicon chromosome
Accession NZ_CP080118
Organism Escherichia coli strain M70

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1X3JHM4
Locus tag KZX75_RS07545 Protein ID WP_001114681.1
Coordinates 1595839..1596732 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID V0YCI1
Locus tag KZX75_RS07550 Protein ID WP_000208383.1
Coordinates 1596725..1597120 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX75_RS07525 (1590989) 1590989..1591972 - 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -
KZX75_RS07530 (1592598) 1592598..1593353 - 756 Protein_1474 IS21-like element ISEc10 family helper ATPase IstB -
KZX75_RS07535 (1593350) 1593350..1594849 - 1500 WP_000174401.1 IS21-like element ISEc10 family transposase -
KZX75_RS07540 (1595198) 1595198..1595368 - 171 Protein_1476 IS110 family transposase -
KZX75_RS07545 (1595839) 1595839..1596732 - 894 WP_001114681.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
KZX75_RS07550 (1596725) 1596725..1597120 - 396 WP_000208383.1 DUF6088 family protein Antitoxin
KZX75_RS07555 (1597189) 1597189..1598034 - 846 WP_023281696.1 DUF4942 domain-containing protein -
KZX75_RS07560 (1598119) 1598119..1598316 - 198 WP_000839293.1 DUF957 domain-containing protein -
KZX75_RS07565 (1598333) 1598333..1598821 - 489 WP_000761699.1 DUF5983 family protein -
KZX75_RS07570 (1598818) 1598818..1599195 - 378 WP_000854689.1 TA system toxin CbtA family protein -
KZX75_RS07575 (1599272) 1599272..1599652 - 381 WP_001285598.1 type IV toxin-antitoxin system YeeU family antitoxin -
KZX75_RS07580 (1599702) 1599702..1600346 - 645 WP_000094916.1 hypothetical protein -
KZX75_RS07585 (1600365) 1600365..1600586 - 222 WP_000692329.1 DUF987 domain-containing protein -
KZX75_RS07590 (1600649) 1600649..1601125 - 477 WP_001186726.1 RadC family protein -
KZX75_RS07595 (1601141) 1601141..1601626 - 486 WP_000849566.1 antirestriction protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-292)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 34298.40 Da        Isoelectric Point: 5.9850

>T210852 WP_001114681.1 NZ_CP080118:c1596732-1595839 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN

Download         Length: 894 bp

>T210852 NZ_CP104638:c4637898-4637371 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGAAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14608.03 Da        Isoelectric Point: 11.3150

>AT210852 WP_000208383.1 NZ_CP080118:c1597120-1596725 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA

Download         Length: 396 bp

>AT210852 NZ_CP104638:c4638185-4637895 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3JHM4

Antitoxin

Source ID Structure
AlphaFold DB V0YCI1

References