Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 762616..763451 Replicon chromosome
Accession NZ_CP080118
Organism Escherichia coli strain M70

Toxin (Protein)


Gene name yeeV Uniprot ID A0A376WVB1
Locus tag KZX75_RS03595 Protein ID WP_001094448.1
Coordinates 762616..762993 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3T7EC32
Locus tag KZX75_RS03600 Protein ID WP_024175935.1
Coordinates 763083..763451 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX75_RS03565 (758457) 758457..759302 - 846 WP_000065751.1 DUF4942 domain-containing protein -
KZX75_RS03570 (759387) 759387..759579 - 193 Protein_686 hypothetical protein -
KZX75_RS03575 (759657) 759657..761270 - 1614 WP_000080195.1 IS66-like element ISEc23 family transposase -
KZX75_RS03580 (761301) 761301..761651 - 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
KZX75_RS03585 (761648) 761648..762073 - 426 WP_000422741.1 transposase -
KZX75_RS03590 (762155) 762155..762619 - 465 WP_061091426.1 DUF5983 family protein -
KZX75_RS03595 (762616) 762616..762993 - 378 WP_001094448.1 TA system toxin CbtA family protein Toxin
KZX75_RS03600 (763083) 763083..763451 - 369 WP_024175935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZX75_RS03605 (763525) 763525..763746 - 222 WP_000692346.1 DUF987 domain-containing protein -
KZX75_RS03610 (763815) 763815..764291 - 477 WP_001186709.1 RadC family protein -
KZX75_RS03615 (764303) 764303..764788 - 486 WP_000214415.1 antirestriction protein -
KZX75_RS03620 (764880) 764880..765698 - 819 WP_001234753.1 DUF932 domain-containing protein -
KZX75_RS03625 (765789) 765789..766022 - 234 WP_001117568.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14221.22 Da        Isoelectric Point: 8.2919

>T210848 WP_001094448.1 NZ_CP080118:c762993-762616 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T210848 NZ_CP104638:3461299-3461610 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13598.40 Da        Isoelectric Point: 6.6255

>AT210848 WP_024175935.1 NZ_CP080118:c763451-763083 [Escherichia coli]
VSDTLSGTTHPDDNDDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT210848 NZ_CP104638:3461607-3462053 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376WVB1

Antitoxin

Source ID Structure
AlphaFold DB A0A3T7EC32

References