Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4396143..4396738 Replicon chromosome
Accession NZ_CP080117
Organism Escherichia coli strain OV24

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag KZX74_RS21455 Protein ID WP_000239579.1
Coordinates 4396143..4396493 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag KZX74_RS21460 Protein ID WP_001223208.1
Coordinates 4396487..4396738 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX74_RS21435 (4391589) 4391589..4392611 - 1023 WP_001296689.1 ABC transporter permease -
KZX74_RS21440 (4392625) 4392625..4394127 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
KZX74_RS21445 (4394267) 4394267..4395223 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KZX74_RS21450 (4395533) 4395533..4396063 + 531 WP_000055075.1 inorganic diphosphatase -
KZX74_RS21455 (4396143) 4396143..4396493 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
KZX74_RS21460 (4396487) 4396487..4396738 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KZX74_RS21465 (4396950) 4396950..4397291 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
KZX74_RS21470 (4397294) 4397294..4401073 - 3780 WP_000060945.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T210842 WP_000239579.1 NZ_CP080117:c4396493-4396143 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T210842 NZ_CP104638:830627-830730 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT210842 WP_001223208.1 NZ_CP080117:c4396738-4396487 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT210842 NZ_CP104638:c830732-830587 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References