Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4296505..4297340 Replicon chromosome
Accession NZ_CP080117
Organism Escherichia coli strain OV24

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag KZX74_RS20960 Protein ID WP_000854759.1
Coordinates 4296505..4296882 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag KZX74_RS20965 Protein ID WP_001295723.1
Coordinates 4296972..4297340 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX74_RS20935 (4292616) 4292616..4294238 - 1623 WP_001295726.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -
KZX74_RS20940 (4295029) 4295029..4295205 - 177 Protein_4126 helix-turn-helix domain-containing protein -
KZX74_RS20945 (4295572) 4295572..4295721 - 150 Protein_4127 hypothetical protein -
KZX74_RS20950 (4295827) 4295827..4296003 - 177 WP_000839286.1 DUF957 domain-containing protein -
KZX74_RS20955 (4296020) 4296020..4296508 - 489 WP_000761690.1 DUF5983 family protein -
KZX74_RS20960 (4296505) 4296505..4296882 - 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
KZX74_RS20965 (4296972) 4296972..4297340 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZX74_RS20970 (4297613) 4297613..4298359 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
KZX74_RS20975 (4298374) 4298374..4299915 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
KZX74_RS20980 (4300056) 4300056..4300310 - 255 WP_023281719.1 DUF987 domain-containing protein -
KZX74_RS20985 (4300373) 4300373..4300849 - 477 WP_001186775.1 RadC family protein -
KZX74_RS20990 (4300865) 4300865..4301338 - 474 WP_001350782.1 antirestriction protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T210841 WP_000854759.1 NZ_CP080117:c4296882-4296505 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T210841 NZ_CP104637:66811-67161 [Salmonella enterica]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT210841 WP_001295723.1 NZ_CP080117:c4297340-4296972 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT210841 NZ_CP104637:67166-67468 [Salmonella enterica]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References