Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1922220..1923051 Replicon chromosome
Accession NZ_CP080117
Organism Escherichia coli strain OV24

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag KZX74_RS09020 Protein ID WP_000854815.1
Coordinates 1922220..1922594 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag KZX74_RS09025 Protein ID WP_001280918.1
Coordinates 1922683..1923051 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX74_RS08980 (1917616) 1917616..1918782 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
KZX74_RS08985 (1918901) 1918901..1919374 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
KZX74_RS08990 (1919572) 1919572..1920630 + 1059 WP_001200889.1 FUSC family protein -
KZX74_RS08995 (1920802) 1920802..1921131 + 330 WP_000450409.1 DUF496 family protein -
KZX74_RS24225 (1921232) 1921232..1921555 - 324 WP_225469267.1 EutP/PduV family microcompartment system protein -
KZX74_RS24230 (1921534) 1921534..1921614 + 81 WP_023441679.1 hypothetical protein -
KZX74_RS09010 (1921903) 1921903..1921983 - 81 Protein_1770 hypothetical protein -
KZX74_RS09015 (1922029) 1922029..1922223 - 195 WP_000988600.1 DUF5983 family protein -
KZX74_RS09020 (1922220) 1922220..1922594 - 375 WP_000854815.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
KZX74_RS09025 (1922683) 1922683..1923051 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZX74_RS09030 (1923067) 1923067..1923711 - 645 WP_000086752.1 hypothetical protein -
KZX74_RS09035 (1923730) 1923730..1923951 - 222 WP_000692345.1 DUF987 domain-containing protein -
KZX74_RS09040 (1924014) 1924014..1924490 - 477 WP_001186200.1 RadC family protein -
KZX74_RS09045 (1924506) 1924506..1924979 - 474 WP_001542276.1 antirestriction protein -
KZX74_RS09050 (1925073) 1925073..1925318 - 246 WP_001164966.1 hypothetical protein -
KZX74_RS09055 (1925318) 1925318..1926136 - 819 WP_001542275.1 DUF932 domain-containing protein -
KZX74_RS09060 (1926357) 1926357..1926767 - 411 WP_000846703.1 hypothetical protein -
KZX74_RS09065 (1926783) 1926783..1927133 - 351 Protein_1781 hypothetical protein -
KZX74_RS09070 (1927216) 1927216..1927962 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T210826 WP_000854815.1 NZ_CP080117:c1922594-1922220 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T210826 NZ_CP104629:2764783-2765037 [Escherichia coli]
ATGAGAAAAAATAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGATTGATGCATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT210826 WP_001280918.1 NZ_CP080117:c1923051-1922683 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT210826 NZ_CP104629:2765034-2765276 [Escherichia coli]
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGAAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References