Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 88060..88895 Replicon chromosome
Accession NZ_CP080117
Organism Escherichia coli strain OV24

Toxin (Protein)


Gene name yeeV Uniprot ID A0A376WVB1
Locus tag KZX74_RS00450 Protein ID WP_001094448.1
Coordinates 88060..88437 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3T7EC32
Locus tag KZX74_RS00455 Protein ID WP_024175935.1
Coordinates 88527..88895 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX74_RS00420 (83428) 83428..84246 + 819 WP_000779409.1 lipoprotein NlpA -
KZX74_RS00425 (84250) 84250..85173 - 924 WP_000535950.1 carboxylate/amino acid/amine transporter -
KZX74_RS00430 (85351) 85351..85848 - 498 WP_000509815.1 hypothetical protein -
KZX74_RS00435 (86441) 86441..87286 - 846 WP_000065751.1 DUF4942 domain-containing protein -
KZX74_RS00440 (87371) 87371..87563 - 193 Protein_87 hypothetical protein -
KZX74_RS00445 (87575) 87575..88063 - 489 WP_000761714.1 DUF5983 family protein -
KZX74_RS00450 (88060) 88060..88437 - 378 WP_001094448.1 TA system toxin CbtA family protein Toxin
KZX74_RS00455 (88527) 88527..88895 - 369 WP_024175935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZX74_RS00460 (88969) 88969..89190 - 222 WP_000692346.1 DUF987 domain-containing protein -
KZX74_RS00465 (89259) 89259..89735 - 477 WP_001186709.1 RadC family protein -
KZX74_RS00470 (89747) 89747..90232 - 486 WP_000214415.1 antirestriction protein -
KZX74_RS00475 (90324) 90324..91142 - 819 WP_001234753.1 DUF932 domain-containing protein -
KZX74_RS00480 (91233) 91233..91466 - 234 WP_001117568.1 DUF905 family protein -
KZX74_RS00485 (91537) 91537..92616 - 1080 Protein_96 autotransporter adhesin family protein -
KZX74_RS00490 (92729) 92729..93154 + 426 WP_000422741.1 transposase -
KZX74_RS00495 (93151) 93151..93501 + 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14221.22 Da        Isoelectric Point: 8.2919

>T210820 WP_001094448.1 NZ_CP080117:c88437-88060 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T210820 NZ_CP104629:c1027429-1027322 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13598.40 Da        Isoelectric Point: 6.6255

>AT210820 WP_024175935.1 NZ_CP080117:c88895-88527 [Escherichia coli]
VSDTLSGTTHPDDNDDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT210820 NZ_CP104629:1027476-1027542 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376WVB1

Antitoxin

Source ID Structure
AlphaFold DB A0A3T7EC32

References