Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3366436..3367090 Replicon chromosome
Accession NZ_CP080116
Organism Escherichia coli strain Dog168

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag KZX73_RS16515 Protein ID WP_000244765.1
Coordinates 3366683..3367090 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag KZX73_RS16510 Protein ID WP_000354050.1
Coordinates 3366436..3366702 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX73_RS16490 (3362524) 3362524..3363957 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
KZX73_RS16495 (3364002) 3364002..3364313 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
KZX73_RS16500 (3364477) 3364477..3365136 + 660 WP_000250275.1 hemolysin III family protein -
KZX73_RS16505 (3365213) 3365213..3366193 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
KZX73_RS16510 (3366436) 3366436..3366702 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
KZX73_RS16515 (3366683) 3366683..3367090 + 408 WP_000244765.1 protein YgfX Toxin
KZX73_RS16520 (3367130) 3367130..3367651 - 522 WP_001055874.1 flavodoxin FldB -
KZX73_RS16525 (3367763) 3367763..3368659 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KZX73_RS16530 (3368684) 3368684..3369394 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KZX73_RS16535 (3369400) 3369400..3371133 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T210808 WP_000244765.1 NZ_CP080116:3366683-3367090 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T210808 NZ_CP104627:723771-724256 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT210808 WP_000354050.1 NZ_CP080116:3366436-3366702 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT210808 NZ_CP104627:723481-723774 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAACCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGCGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References