Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3221342..3222176 | Replicon | chromosome |
| Accession | NZ_CP080116 | ||
| Organism | Escherichia coli strain Dog168 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PLF5 |
| Locus tag | KZX73_RS15755 | Protein ID | WP_000854690.1 |
| Coordinates | 3221342..3221719 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P7N8 |
| Locus tag | KZX73_RS15760 | Protein ID | WP_001305076.1 |
| Coordinates | 3221808..3222176 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZX73_RS15725 (3217736) | 3217736..3217906 | - | 171 | Protein_3083 | IS110 family transposase | - |
| KZX73_RS15730 (3218323) | 3218323..3219256 | - | 934 | Protein_3084 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| KZX73_RS15735 (3219249) | 3219249..3219644 | - | 396 | WP_000208384.1 | DUF6088 family protein | - |
| KZX73_RS15740 (3219713) | 3219713..3220558 | - | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| KZX73_RS15745 (3220643) | 3220643..3220840 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| KZX73_RS15750 (3220857) | 3220857..3221345 | - | 489 | WP_000761699.1 | DUF5983 family protein | - |
| KZX73_RS15755 (3221342) | 3221342..3221719 | - | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
| KZX73_RS15760 (3221808) | 3221808..3222176 | - | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| KZX73_RS15765 (3222226) | 3222226..3222870 | - | 645 | WP_000094916.1 | hypothetical protein | - |
| KZX73_RS15770 (3222889) | 3222889..3223110 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| KZX73_RS15775 (3223173) | 3223173..3223649 | - | 477 | WP_001186726.1 | RadC family protein | - |
| KZX73_RS15780 (3223665) | 3223665..3224150 | - | 486 | WP_000849565.1 | antirestriction protein | - |
| KZX73_RS15785 (3224205) | 3224205..3225023 | - | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| KZX73_RS15790 (3225124) | 3225124..3225357 | - | 234 | WP_000902034.1 | DUF905 family protein | - |
| KZX73_RS15795 (3225436) | 3225436..3225891 | - | 456 | WP_000581502.1 | IrmA family protein | - |
| KZX73_RS15800 (3225967) | 3225967..3227094 | - | 1128 | Protein_3098 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 3217736..3217891 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T210807 WP_000854690.1 NZ_CP080116:c3221719-3221342 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T210807 NZ_CP104627:322608-322976 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13560.39 Da Isoelectric Point: 4.7830
>AT210807 WP_001305076.1 NZ_CP080116:c3222176-3221808 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT210807 NZ_CP104627:322390-322611 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|