Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1603750..1604585 Replicon chromosome
Accession NZ_CP080116
Organism Escherichia coli strain Dog168

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag KZX73_RS08055 Protein ID WP_000854759.1
Coordinates 1603750..1604127 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag KZX73_RS08060 Protein ID WP_001295723.1
Coordinates 1604217..1604585 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX73_RS08030 (1599861) 1599861..1601483 - 1623 WP_001295726.1 Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase -
KZX73_RS08035 (1602274) 1602274..1602450 - 177 Protein_1579 helix-turn-helix domain-containing protein -
KZX73_RS08040 (1602817) 1602817..1602966 - 150 Protein_1580 hypothetical protein -
KZX73_RS08045 (1603072) 1603072..1603248 - 177 WP_000839286.1 DUF957 domain-containing protein -
KZX73_RS08050 (1603265) 1603265..1603753 - 489 WP_000761690.1 DUF5983 family protein -
KZX73_RS08055 (1603750) 1603750..1604127 - 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
KZX73_RS08060 (1604217) 1604217..1604585 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZX73_RS08065 (1604858) 1604858..1605604 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
KZX73_RS08070 (1605619) 1605619..1607160 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
KZX73_RS08075 (1607301) 1607301..1607555 - 255 WP_023281719.1 DUF987 domain-containing protein -
KZX73_RS08080 (1607618) 1607618..1608094 - 477 WP_001186775.1 RadC family protein -
KZX73_RS08085 (1608110) 1608110..1608583 - 474 WP_001350782.1 antirestriction protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T210799 WP_000854759.1 NZ_CP080116:c1604127-1603750 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T210799 NZ_CP104619:92141-92662 [Escherichia coli]
GTGAGCAATACGACGATCGAGATTTTCTCTGGAGAGAACGATTATGATCTAAACGGTTTTGATTGCGGCGAAGAGTCACT
AAACGCATTTTTGACCAACCACTTAAAAAGACAGCATGAAGGAAAAATTCTTCGCGCTTATGTGCTTTGCACTAAAGAAG
AAATACCAAAGGTATTAGGTTATTACACTTTGTCAGGCAGCTGCTTTGAGAAAGAAACCTTACCTTCAAAGAGTCAGCAA
AAGAAAGTGCCTTATCGGAATGTCCCAAGTATCACTTTAGGCAGACTGGCTTTGGACAAATCTCTTCAAGGTCAGGGGCT
TGGCTCAATGCTTGTAACTCACGCAATGCGTGTTGTGTACAATGCATCTCTTGCGGTAGGCATTCATGGGCTTTTCGTTG
AGGCGTTGAACGATAAAGCTAGGGCGTTTTATAAAAGTTTGGGCTTTATCCAGCTGGTTGGTAACAACGATCGTTCTTTG
TTCTATCCAACAAAATCTATCGAAAAATTGTTCGAAGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT210799 WP_001295723.1 NZ_CP080116:c1604585-1604217 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT210799 NZ_CP104619:91864-92133 [Escherichia coli]
ATGTCCGCACTGAAAAAGCAGCGCATCGATTTGAGATTAACCGATGACGATAAAAGCATCATCGAGGAAGCTGCCGCAAT
GTCTAACCAGAGCATTACCCAGTTCATGGTTAGCAGTGCATCCGAACGTGCCGTGAAGGTGATAGAGCAACACCGTAGAC
TGGTTCTAAGTGAAGAGTCCTGGAATCTGGTTATGGATGCTATAAGCAATCCTCCGGCACCGAACGACAAGCTGAAACGA
GCTGCCAATCGTCTGAAAAGCATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References