Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 1145353..1147042 | Replicon | chromosome |
| Accession | NZ_CP080116 | ||
| Organism | Escherichia coli strain Dog168 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A061KTE0 |
| Locus tag | KZX73_RS05850 | Protein ID | WP_000365807.1 |
| Coordinates | 1145353..1146273 (-) | Length | 307 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | KZX73_RS05855 | Protein ID | WP_001295795.1 |
| Coordinates | 1146260..1147042 (-) | Length | 261 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZX73_RS05810 (1140826) | 1140826..1141536 | + | 711 | WP_001295798.1 | fimbrial chaperone EcpE | - |
| KZX73_RS05815 (1141843) | 1141843..1142172 | + | 330 | WP_001295797.1 | YkgJ family cysteine cluster protein | - |
| KZX73_RS05820 (1142184) | 1142184..1142350 | - | 167 | Protein_1146 | tail fiber assembly protein | - |
| KZX73_RS05825 (1142421) | 1142421..1143035 | - | 615 | WP_001019923.1 | YagU family protein | - |
| KZX73_RS05830 (1143250) | 1143250..1143435 | - | 186 | WP_000146240.1 | hypothetical protein | - |
| KZX73_RS05835 (1143484) | 1143484..1143642 | + | 159 | Protein_1149 | integrase | - |
| KZX73_RS05840 (1143869) | 1143869..1144204 | + | 336 | WP_000996167.1 | Arm DNA-binding domain-containing protein | - |
| KZX73_RS05845 (1144412) | 1144412..1145188 | + | 777 | WP_000171155.1 | site-specific integrase | - |
| KZX73_RS05850 (1145353) | 1145353..1146273 | - | 921 | WP_000365807.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| KZX73_RS05855 (1146260) | 1146260..1147042 | - | 783 | WP_001295795.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| KZX73_RS05860 (1147326) | 1147326..1150424 | + | 3099 | WP_000673070.1 | type I restriction endonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE | 1105137..1154105 | 48968 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 307 a.a. Molecular weight: 34570.89 Da Isoelectric Point: 7.3239
>T210796 WP_000365807.1 NZ_CP080116:c1146273-1145353 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE
Download Length: 921 bp
>T210796 NZ_CP104618:c4018154-4017813 [Escherichia coli]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCGCCCGTCGTGGTCTGGCAAACATTACTGAC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTCGATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCAGTCGATATTTTGCGGGCGCGGCAGGCTACAGGTCTGCTGCGTCGCAG
CCATAACACCACGGCACGGTGA
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCGCCCGTCGTGGTCTGGCAAACATTACTGAC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTCGATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCAGTCGATATTTTGCGGGCGCGGCAGGCTACAGGTCTGCTGCGTCGCAG
CCATAACACCACGGCACGGTGA
Antitoxin
Download Length: 261 a.a. Molecular weight: 29099.24 Da Isoelectric Point: 8.5975
>AT210796 WP_001295795.1 NZ_CP080116:c1147042-1146260 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA
Download Length: 783 bp
>AT210796 NZ_CP104618:c4018520-4018185 [Escherichia coli]
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGCTGATGAAACAACTGGAGCTGAAACTGGCTGACGGTGAACTCTCCGCCTGCCAAAAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA
ATGCTGCAAAAGGACAAGGTCATGCAACAAGAATGGGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGCTGATGAAACAACTGGAGCTGAAACTGGCTGACGGTGAACTCTCCGCCTGCCAAAAACGT
ACCGTCACGCTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|