Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 60825..61351 Replicon plasmid pWW19C-IncFIB
Accession NZ_CP080109
Organism Enterobacter asburiae strain WW-19C

Toxin (Protein)


Gene name relE Uniprot ID A0A7R6HXL1
Locus tag KZX48_RS25425 Protein ID WP_015572079.1
Coordinates 61064..61351 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KZX48_RS25420 Protein ID WP_000534858.1
Coordinates 60825..61064 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX48_RS25400 (KZX48_25390) 56765..57811 - 1047 WP_045325187.1 NAD(P)-dependent alcohol dehydrogenase -
KZX48_RS25405 (KZX48_25395) 57828..59045 - 1218 WP_072206003.1 MFS transporter -
KZX48_RS25410 (KZX48_25400) 59173..59634 - 462 WP_226858106.1 cyclophilin-like fold protein -
KZX48_RS25415 (KZX48_25405) 59751..60650 + 900 WP_045325182.1 LysR family transcriptional regulator -
KZX48_RS26260 60701..60800 - 100 Protein_61 hypothetical protein -
KZX48_RS25420 (KZX48_25410) 60825..61064 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KZX48_RS25425 (KZX48_25415) 61064..61351 + 288 WP_015572079.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZX48_RS25430 (KZX48_25420) 61423..61581 + 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
KZX48_RS25435 (KZX48_25425) 62305..62913 + 609 WP_094935623.1 hypothetical protein -
KZX48_RS25440 (KZX48_25430) 62942..63730 + 789 WP_015572118.1 DsbA family protein -
KZX48_RS25445 (KZX48_25435) 64311..64931 + 621 Protein_67 plasmid replication initiator RepA -
KZX48_RS25450 (KZX48_25440) 65207..66211 - 1005 WP_000427623.1 IS110-like element IS4321 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1A - 1..139140 139140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11209.09 Da        Isoelectric Point: 10.0714

>T210793 WP_015572079.1 NZ_CP080109:61064-61351 [Enterobacter asburiae]
MAYFLDFDERALKEWRKLGSTVREQLKNKLAEVLESPRIDANKLRGMHDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T210793 NZ_CP104618:c3622624-3622226 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT210793 WP_000534858.1 NZ_CP080109:60825-61064 [Enterobacter asburiae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT210793 NZ_CP104618:c3622920-3622627 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References