Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 4733779..4734395 Replicon chromosome
Accession NZ_CP080107
Organism Enterobacter asburiae strain WW-19C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KZX48_RS23020 Protein ID WP_094935277.1
Coordinates 4733779..4734150 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KZX48_RS23025 Protein ID WP_094935276.1
Coordinates 4734153..4734395 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX48_RS23005 (KZX48_22995) 4731279..4732181 + 903 WP_010436855.1 formate dehydrogenase subunit beta -
KZX48_RS23010 (KZX48_23000) 4732178..4732813 + 636 WP_010436852.1 formate dehydrogenase cytochrome b556 subunit -
KZX48_RS23015 (KZX48_23005) 4732810..4733739 + 930 WP_023309751.1 formate dehydrogenase accessory protein FdhE -
KZX48_RS23020 (KZX48_23010) 4733779..4734150 - 372 WP_094935277.1 type II toxin-antitoxin system VapC family toxin Toxin
KZX48_RS23025 (KZX48_23015) 4734153..4734395 - 243 WP_094935276.1 CopG family transcriptional regulator Antitoxin
KZX48_RS23030 (KZX48_23020) 4734595..4735515 + 921 WP_094935275.1 alpha/beta hydrolase -
KZX48_RS23035 (KZX48_23025) 4735524..4736465 - 942 WP_039264191.1 fatty acid biosynthesis protein FabY -
KZX48_RS23040 (KZX48_23030) 4736510..4736947 - 438 WP_008501836.1 D-aminoacyl-tRNA deacylase -
KZX48_RS23045 (KZX48_23035) 4736944..4737825 - 882 WP_033146965.1 virulence factor BrkB family protein -
KZX48_RS23050 (KZX48_23040) 4737819..4738418 - 600 WP_094935274.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4733779..4743340 9561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13680.87 Da        Isoelectric Point: 7.3604

>T210791 WP_094935277.1 NZ_CP080107:c4734150-4733779 [Enterobacter asburiae]
MERMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEAKTATVMGVFEIIDITRDIAERSVILR
EKHGMKLPDAIILATAQSRSCPLISRNTKDFSGITGVVSPYQL

Download         Length: 372 bp

>T210791 NZ_CP104618:2641734-2641841 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9455.65 Da        Isoelectric Point: 4.2803

>AT210791 WP_094935276.1 NZ_CP080107:c4734395-4734153 [Enterobacter asburiae]
MILSADLDMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT210791 NZ_CP104618:c2641687-2641621 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References