Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3986418..3987075 Replicon chromosome
Accession NZ_CP080107
Organism Enterobacter asburiae strain WW-19C

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag KZX48_RS19275 Protein ID WP_021242050.1
Coordinates 3986418..3986828 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag KZX48_RS19280 Protein ID WP_010435322.1
Coordinates 3986809..3987075 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX48_RS19255 (KZX48_19245) 3982411..3984144 - 1734 WP_039262981.1 single-stranded-DNA-specific exonuclease RecJ -
KZX48_RS19260 (KZX48_19250) 3984150..3984863 - 714 WP_023309097.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KZX48_RS19265 (KZX48_19255) 3984892..3985788 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
KZX48_RS19270 (KZX48_19260) 3985890..3986411 + 522 WP_064673272.1 flavodoxin FldB -
KZX48_RS19275 (KZX48_19265) 3986418..3986828 - 411 WP_021242050.1 protein YgfX Toxin
KZX48_RS19280 (KZX48_19270) 3986809..3987075 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
KZX48_RS19285 (KZX48_19275) 3987370..3988350 + 981 WP_029739202.1 tRNA-modifying protein YgfZ -
KZX48_RS19290 (KZX48_19280) 3988425..3989084 - 660 WP_033146591.1 hemolysin III family protein -
KZX48_RS19295 (KZX48_19285) 3989250..3989561 - 312 WP_094935379.1 N(4)-acetylcytidine aminohydrolase -
KZX48_RS19300 (KZX48_19290) 3989613..3990344 + 732 WP_029739204.1 MurR/RpiR family transcriptional regulator -
KZX48_RS19305 (KZX48_19295) 3990461..3991894 + 1434 WP_033146593.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T210790 WP_021242050.1 NZ_CP080107:c3986828-3986418 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T210790 NZ_CP104618:2641199-2641306 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT210790 WP_010435322.1 NZ_CP080107:c3987075-3986809 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT210790 NZ_CP104618:c2641152-2641086 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References