Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1175128..1175748 Replicon chromosome
Accession NZ_CP080107
Organism Enterobacter asburiae strain WW-19C

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag KZX48_RS05655 Protein ID WP_008499287.1
Coordinates 1175128..1175346 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag KZX48_RS05660 Protein ID WP_008499288.1
Coordinates 1175374..1175748 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX48_RS05625 (KZX48_05625) 1171142..1171402 + 261 WP_045356432.1 type B 50S ribosomal protein L31 -
KZX48_RS05630 (KZX48_05630) 1171405..1171545 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
KZX48_RS05635 (KZX48_05635) 1171542..1172252 - 711 WP_087822105.1 GNAT family protein -
KZX48_RS05640 (KZX48_05640) 1172354..1173814 + 1461 WP_094934746.1 PLP-dependent aminotransferase family protein -
KZX48_RS05645 (KZX48_05645) 1173786..1174253 - 468 WP_045400719.1 YlaC family protein -
KZX48_RS05650 (KZX48_05650) 1174371..1174922 - 552 WP_047061252.1 maltose O-acetyltransferase -
KZX48_RS05655 (KZX48_05655) 1175128..1175346 - 219 WP_008499287.1 HHA domain-containing protein Toxin
KZX48_RS05660 (KZX48_05660) 1175374..1175748 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
KZX48_RS05665 (KZX48_05665) 1176260..1179406 - 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit AcrB -
KZX48_RS05670 (KZX48_05670) 1179429..1180622 - 1194 WP_029741963.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T210779 WP_008499287.1 NZ_CP080107:c1175346-1175128 [Enterobacter asburiae]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T210779 NZ_CP104618:181072-181179 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT210779 WP_008499288.1 NZ_CP080107:c1175748-1175374 [Enterobacter asburiae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT210779 NZ_CP104618:c181024-180958 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References