Detailed information of TA system TA210778

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 1018941..1019620
• Replicon: chromosome
• Accession: NZ_CP080107
• Organism: Enterobacter asburiae strain WW-19C

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: -
• Locus tag: KZX48_RS04865
• Protein ID: WP_193362634.1
• Coordinates: 1018941..1019282 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: KZX48_RS04870
• Protein ID: WP_101700290.1
• Coordinates: 1019303..1019620 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZX48_RS04840 (KZX48_04840)	1014106..1014507	+	402	WP_023310506.1	sigma factor-binding protein Crl	-
KZX48_RS04845 (KZX48_04845)	1014647..1015699	-	1053	WP_033144705.1	phosphoporin PhoE	-
KZX48_RS04850 (KZX48_04850)	1016004..1017107	+	1104	WP_023310508.1	glutamate 5-kinase	-
KZX48_RS04855 (KZX48_04855)	1017119..1018372	+	1254	WP_094935652.1	glutamate-5-semialdehyde dehydrogenase	-
KZX48_RS04865 (KZX48_04865)	1018941..1019282	-	342	WP_193362634.1	type IV toxin-antitoxin system toxin YkfI	Toxin
KZX48_RS04870 (KZX48_04870)	1019303..1019620	-	318	WP_101700290.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KZX48_RS04875 (KZX48_04875)	1019640..1019861	-	222	WP_000691995.1	DUF987 domain-containing protein	-
KZX48_RS04880 (KZX48_04880)	1019870..1020346	-	477	WP_193362635.1	RadC family protein	-
KZX48_RS04885 (KZX48_04885)	1020362..1020820	-	459	WP_000211838.1	antirestriction protein	-
KZX48_RS04890 (KZX48_04890)	1020918..1021157	-	240	WP_000194654.1	DUF905 family protein	-
KZX48_RS04895 (KZX48_04895)	1021234..1021701	-	468	WP_001547765.1	protein YkfB	-
KZX48_RS04900 (KZX48_04900)	1021730..1022167	-	438	WP_016154551.1	lipoprotein YafY	-
KZX48_RS04905 (KZX48_04905)	1022167..1022403	-	237	WP_001144031.1	protein YpjK	-
KZX48_RS04910 (KZX48_04910)	1022444..1023145	-	702	WP_001547763.1	WYL domain-containing protein	-
KZX48_RS04915 (KZX48_04915)	1023362..1024183	-	822	WP_001547762.1	DUF932 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1018721..1054448	35727

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12925.01 Da
• Isoelectric Point: 9.6543

>T210778 WP_193362634.1 NZ_CP080107:c1019282-1018941 [Enterobacter asburiae]
MKTLPATTQRAVKPCLSPMAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR

Nucleotide

• Length: 342 bp

>T210778 NZ_CP104615:c63231-62950 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11943.56 Da
• Isoelectric Point: 7.3476

>AT210778 WP_101700290.1 NZ_CP080107:c1019620-1019303 [Enterobacter asburiae]
MTHINWGLQRAITPRLGARLVQEGNRLHYLADRASITGRFSDTECRKLDETCPHFIRQMESMLTTGELSPQHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp

>AT210778 NZ_CP104615:c63472-63221 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA