Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | shpAB/BrnT-BrnA |
Location | 701959..702535 | Replicon | chromosome |
Accession | NZ_CP080107 | ||
Organism | Enterobacter asburiae strain WW-19C |
Toxin (Protein)
Gene name | shpA | Uniprot ID | A0A4R0G892 |
Locus tag | KZX48_RS03385 | Protein ID | WP_010427219.1 |
Coordinates | 701959..702246 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | shpB | Uniprot ID | A0A411GC49 |
Locus tag | KZX48_RS03390 | Protein ID | WP_033144548.1 |
Coordinates | 702233..702535 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KZX48_RS03360 (KZX48_03360) | 697059..697754 | + | 696 | WP_094935517.1 | winged helix-turn-helix domain-containing protein | - |
KZX48_RS03365 (KZX48_03365) | 697905..698375 | + | 471 | WP_094935516.1 | MarR family transcriptional regulator | - |
KZX48_RS03370 (KZX48_03370) | 698372..699439 | + | 1068 | WP_094935515.1 | HlyD family secretion protein | - |
KZX48_RS03375 (KZX48_03375) | 699444..700520 | + | 1077 | WP_023310256.1 | DUF2955 domain-containing protein | - |
KZX48_RS03380 (KZX48_03380) | 700517..701788 | - | 1272 | WP_094935514.1 | DUF445 domain-containing protein | - |
KZX48_RS03385 (KZX48_03385) | 701959..702246 | + | 288 | WP_010427219.1 | BrnT family toxin | Toxin |
KZX48_RS03390 (KZX48_03390) | 702233..702535 | + | 303 | WP_033144548.1 | BrnA antitoxin family protein | Antitoxin |
KZX48_RS03395 (KZX48_03395) | 702566..703204 | - | 639 | WP_094935513.1 | LysE family translocator | - |
KZX48_RS03400 (KZX48_03400) | 703252..703995 | - | 744 | WP_048976422.1 | AraC family transcriptional regulator | - |
KZX48_RS03405 (KZX48_03405) | 704147..705517 | + | 1371 | WP_094935512.1 | NAD-dependent succinate-semialdehyde dehydrogenase | - |
KZX48_RS03410 (KZX48_03410) | 705564..705884 | - | 321 | WP_039262264.1 | hypothetical protein | - |
KZX48_RS03415 (KZX48_03415) | 705884..706429 | - | 546 | WP_023310269.1 | YfaZ family outer membrane protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11174.64 Da Isoelectric Point: 6.7609
>T210777 WP_010427219.1 NZ_CP080107:701959-702246 [Enterobacter asburiae]
MPTEFEWDTNKAKSNLIKHGIRFEEAVLVFDDPYHLSLQDRHENGEFRWQTIGLVHGLIVIMVAHTVRFESGDEVIRIIS
ARKADRKERSRYEHG
MPTEFEWDTNKAKSNLIKHGIRFEEAVLVFDDPYHLSLQDRHENGEFRWQTIGLVHGLIVIMVAHTVRFESGDEVIRIIS
ARKADRKERSRYEHG
Download Length: 288 bp
>T210777 NZ_CP104615:34476-34892 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11395.04 Da Isoelectric Point: 10.2483
>AT210777 WP_033144548.1 NZ_CP080107:702233-702535 [Enterobacter asburiae]
MSMVKHKRGSAPEMSARREAELKALAEKSEAEIDYSDIPATGDEQWSGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK
MSMVKHKRGSAPEMSARREAELKALAEKSEAEIDYSDIPATGDEQWSGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK
Download Length: 303 bp
>AT210777 NZ_CP104615:34249-34479 [Escherichia coli]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4R0G892 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A411GC49 |