Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4962598..4963114 Replicon chromosome
Accession NZ_CP080099
Organism Klebsiella quasipneumoniae strain WW-14A

Toxin (Protein)


Gene name relE Uniprot ID A0A8B4FZD2
Locus tag KZX49_RS24445 Protein ID WP_048336510.1
Coordinates 4962598..4962882 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1C1EW86
Locus tag KZX49_RS24450 Protein ID WP_023291757.1
Coordinates 4962872..4963114 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX49_RS24435 (4959596) 4959596..4961734 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
KZX49_RS24440 (4962130) 4962130..4962594 + 465 WP_012969085.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KZX49_RS24445 (4962598) 4962598..4962882 - 285 WP_048336510.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZX49_RS24450 (4962872) 4962872..4963114 - 243 WP_023291757.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KZX49_RS24455 (4963192) 4963192..4965102 - 1911 WP_044525201.1 PRD domain-containing protein -
KZX49_RS24460 (4965125) 4965125..4966279 - 1155 WP_219804065.1 lactonase family protein -
KZX49_RS24465 (4966347) 4966347..4967087 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-70)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10956.81 Da        Isoelectric Point: 10.4974

>T210773 WP_048336510.1 NZ_CP080099:c4962882-4962598 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWQKLGETIKKQFKNKLQQVVQNPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T210773 NZ_CP104613:c4373297-4373022 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9119.58 Da        Isoelectric Point: 4.8146

>AT210773 WP_023291757.1 NZ_CP080099:c4963114-4962872 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Download         Length: 243 bp

>AT210773 NZ_CP104613:c4373025-4372666 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4FZD2

Antitoxin

Source ID Structure
AlphaFold DB A0A1C1EW86

References