Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4141436..4142055 Replicon chromosome
Accession NZ_CP080099
Organism Klebsiella quasipneumoniae strain WW-14A

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KZX49_RS20375 Protein ID WP_002892050.1
Coordinates 4141837..4142055 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KZX49_RS20370 Protein ID WP_002892066.1
Coordinates 4141436..4141810 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX49_RS20360 (4136590) 4136590..4137783 + 1194 WP_023288645.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KZX49_RS20365 (4137806) 4137806..4140952 + 3147 WP_023288644.1 multidrug efflux RND transporter permease subunit AcrB -
KZX49_RS20370 (4141436) 4141436..4141810 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KZX49_RS20375 (4141837) 4141837..4142055 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KZX49_RS20380 (4142214) 4142214..4142780 + 567 WP_219803934.1 maltose O-acetyltransferase -
KZX49_RS20385 (4142752) 4142752..4142883 - 132 WP_032428629.1 hypothetical protein -
KZX49_RS20390 (4142917) 4142917..4143387 + 471 WP_023288642.1 YlaC family protein -
KZX49_RS20395 (4143356) 4143356..4144813 - 1458 WP_085551203.1 PLP-dependent aminotransferase family protein -
KZX49_RS20400 (4144914) 4144914..4145612 + 699 WP_032453932.1 GNAT family protein -
KZX49_RS20405 (4145609) 4145609..4145749 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KZX49_RS20410 (4145749) 4145749..4146012 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T210772 WP_002892050.1 NZ_CP080099:4141837-4142055 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T210772 NZ_CP104613:c4351686-4351159 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCATTCAATACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCAGTAGGTATTCACGGTCTTTTTGTAG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCGTTGGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT210772 WP_002892066.1 NZ_CP080099:4141436-4141810 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT210772 NZ_CP104613:c4351959-4351693 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGTAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References