Detailed information of TA system TA210761

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1205840..1206507
• Replicon: chromosome
• Accession: NZ_CP080099
• Organism: Klebsiella quasipneumoniae strain WW-14A

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: KZX49_RS05990
• Protein ID: WP_219804141.1
• Coordinates: 1205840..1206169 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: KZX49_RS05995
• Protein ID: WP_064791160.1
• Coordinates: 1206190..1206507 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZX49_RS05970 (1201714)	1201714..1202514	+	801	WP_085551737.1	hypothetical protein	-
KZX49_RS05975 (1202657)	1202657..1203019	-	363	WP_032453772.1	cupin domain-containing protein	-
KZX49_RS05980 (1203469)	1203469..1204035	-	567	WP_065805849.1	XRE family transcriptional regulator	-
KZX49_RS05985 (1204437)	1204437..1205177	-	741	WP_048335038.1	SDR family oxidoreductase	-
KZX49_RS29785 (1205274)	1205274..1205458	-	185	Protein_1175	integrase	-
KZX49_RS05990 (1205840)	1205840..1206169	-	330	WP_219804141.1	TA system toxin CbtA family protein	Toxin
KZX49_RS05995 (1206190)	1206190..1206507	-	318	WP_064791160.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KZX49_RS06000 (1206526)	1206526..1206747	-	222	WP_219804142.1	DUF987 domain-containing protein	-
KZX49_RS06005 (1206756)	1206756..1207232	-	477	WP_064791162.1	RadC family protein	-
KZX49_RS06010 (1207248)	1207248..1207706	-	459	WP_219804143.1	antirestriction protein	-
KZX49_RS06015 (1207792)	1207792..1208028	-	237	WP_219804144.1	DUF905 domain-containing protein	-
KZX49_RS06020 (1208106)	1208106..1208516	-	411	WP_064791165.1	hypothetical protein	-
KZX49_RS06025 (1208583)	1208583..1209020	-	438	WP_219804145.1	hypothetical protein	-
KZX49_RS06030 (1209062)	1209062..1209598	-	537	WP_219804146.1	DUF4339 domain-containing protein	-
KZX49_RS06035 (1209624)	1209624..1210331	-	708	WP_219804147.1	DeoR family transcriptional regulator	-
KZX49_RS06040 (1210540)	1210540..1211364	-	825	WP_219804148.1	DUF932 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12301.22 Da
• Isoelectric Point: 9.9232

>T210761 WP_219804141.1 NZ_CP080099:c1206169-1205840 [Klebsiella quasipneumoniae]
MKPQPATTSRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFSDETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILRARRSTGLLKTNVK

Nucleotide

• Length: 330 bp

>T210761 NZ_CP104613:c2128014-2127736 [Escherichia coli]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11907.56 Da
• Isoelectric Point: 6.6203

>AT210761 WP_064791160.1 NZ_CP080099:c1206507-1206190 [Klebsiella quasipneumoniae]
MSNTTWGLQRDITPRLGARLVQEGNRLHYLADRACITGKFSDAECQKLDVAFPHFISQMESMLITGELNPRHAHCVILYH
NDFTCEADTIGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp

>AT210761 NZ_CP104613:c2127736-2127452 [Escherichia coli]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGATGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCTCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGCCTGGCAGAGGCTGAA
AAAACGGTGGATGTGTCGCGACTACGCCGTCTGGTTACGCAATAA