Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 811087..811744 Replicon chromosome
Accession NZ_CP080099
Organism Klebsiella quasipneumoniae strain WW-14A

Toxin (Protein)


Gene name cptA Uniprot ID A0A5D1WGJ3
Locus tag KZX49_RS04065 Protein ID WP_072420599.1
Coordinates 811334..811744 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KZX49_RS04060 Protein ID WP_002916312.1
Coordinates 811087..811353 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZX49_RS04035 (806237) 806237..807670 - 1434 WP_023290972.1 6-phospho-beta-glucosidase BglA -
KZX49_RS04040 (807789) 807789..808517 - 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
KZX49_RS04045 (808568) 808568..808879 + 312 WP_023290970.1 N(4)-acetylcytidine aminohydrolase -
KZX49_RS04050 (809043) 809043..809702 + 660 WP_008806429.1 hemolysin III family protein -
KZX49_RS04055 (809858) 809858..810841 - 984 WP_023290969.1 tRNA-modifying protein YgfZ -
KZX49_RS04060 (811087) 811087..811353 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KZX49_RS04065 (811334) 811334..811744 + 411 WP_072420599.1 protein YgfX Toxin
KZX49_RS04070 (811751) 811751..812272 - 522 WP_004205324.1 flavodoxin FldB -
KZX49_RS04075 (812373) 812373..813269 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KZX49_RS04080 (813292) 813292..814005 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KZX49_RS04085 (814011) 814011..815744 + 1734 WP_032454029.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16089.92 Da        Isoelectric Point: 11.4778

>T210760 WP_072420599.1 NZ_CP080099:811334-811744 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWIINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T210760 NZ_CP104613:c1872634-1872527 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT210760 WP_002916312.1 NZ_CP080099:811087-811353 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT210760 NZ_CP104613:1872681-1872747 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D1WGJ3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References