Detailed information of TA system TA021076

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 21282..21816
• Replicon: plasmid pYV
• Accession: NC_006153
• Organism: Yersinia pseudotuberculosis IP 32953

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q663N8
• Locus tag: YPTB_RS21600
• Protein ID: WP_002213360.1
• Coordinates: 21282..21581 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: YPTB_RS21605
• Protein ID: WP_012414146.1
• Coordinates: 21574..21816 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPTB_RS21565	16714..17139	-	426	WP_002213267.1	type III secretion system chaperone SycH	-
YPTB_RS21570	17517..17915	-	399	Protein_22	ATP-binding protein	-
YPTB_RS21575	17915..19087	-	1173	WP_011191364.1	IS21 family transposase	-
YPTB_RS21585	19190..19834	+	645	Protein_24	IS3 family transposase	-
YPTB_RS21590	19897..20289	-	393	WP_002213403.1	type III secretion system chaperone SycE/YerA	-
YPTB_RS21595	20483..21142	+	660	WP_002229754.1	type III secretion system effector GTPase activator YopE	-
YPTB_RS21600	21282..21581	-	300	WP_002213360.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
YPTB_RS21605	21574..21816	-	243	WP_012414146.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
YPTB_RS23455	21982..22274	-	293	Protein_29	IS6 family transposase	-
YPTB_RS24165	22359..22532	+	174	WP_002213357.1	hypothetical protein	-
YPTB_RS23975	22682..22963	-	282	WP_157868821.1	hypothetical protein	-
YPTB_RS21615	23123..24088	-	966	WP_011191369.1	ParB/RepB/Spo0J family plasmid partition protein	-
YPTB_RS21620	24085..25251	-	1167	WP_002220902.1	plasmid-partitioning protein SopA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	yopO/ypkA / yadA / sycH / sycE/yerA / yopE / yopK/yopQ / yopT / sycT / yopD / yopB / sycD/lcrH / lcrV / lcrG / lcrR / yscV/lcrD / yscY / yscX / sycN / tyeA / lcrE/yopN / yscN / yscO / yscP / yscQ / yscR / yscS / yscT / yscU / virG/yscW / yscB / yscC / yscD / yscE / yscF / yscG / yopR/yscH/lcrP / lcrO/yscI / ylpB/yscJ / yscK / yscL / lcrQ/yscM / yopH / yopJ/yopP	1..68525	68525

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11632.19 Da
• Isoelectric Point: 5.5114

>T21076 WP_002213360.1 NC_006153:c21581-21282 [Yersinia pseudotuberculosis IP 32953]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNPELGAECNWICSDIRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDVQDFPEHE

Nucleotide

• Length: 300 bp

>T21076 NC_006153:c21581-21282 [Yersinia pseudotuberculosis IP 32953]
GTGTATAAACTGTCTGAACTAGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCCAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCTGATATTCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGTTCAGGATTTTCCAGAGCATGAGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8807.12 Da
• Isoelectric Point: 6.8783

>AT21076 WP_012414146.1 NC_006153:c21816-21574 [Yersinia pseudotuberculosis IP 32953]
MAHVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNVPVSHRLMDEIFSAAVKGTSV

Nucleotide

• Length: 243 bp

>AT21076 NC_006153:c21816-21574 [Yersinia pseudotuberculosis IP 32953]
ATGGCTCACGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TGCTTGCAGGAACAAATGTACCTGTGAGCCATCGTTTAATGGATGAGATTTTTTCTGCTGCGGTGAAAGGTACTAGTGTA
TAA

Structures

Toxin

• AlphaFold DB: Q663N8