Detailed information of TA system TA210758

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2938401..2938960
• Replicon: chromosome
• Accession: NZ_CP080098
• Organism: Vibrio harveyi strain

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KZR01_RS24355
• Protein ID: WP_065788201.1
• Coordinates: 2938682..2938960 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR21
• Locus tag: KZR01_RS24350
• Protein ID: WP_005398409.1
• Coordinates: 2938401..2938685 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZR01_RS24295	2933487..2934494	-	1008	WP_259556205.1	hypothetical protein	-
KZR01_RS24300	2934531..2934623	-	93	WP_259556206.1	DUF3265 domain-containing protein	-
KZR01_RS24305	2934638..2935414	-	777	WP_259556207.1	hypothetical protein	-
KZR01_RS24310	2935535..2935627	-	93	WP_259556208.1	DUF3265 domain-containing protein	-
KZR01_RS24315	2935642..2936295	-	654	WP_259556209.1	hypothetical protein	-
KZR01_RS24320	2936323..2936442	-	120	WP_259557767.1	DUF3265 domain-containing protein	-
KZR01_RS24325	2936436..2936966	-	531	WP_069498697.1	hypothetical protein	-
KZR01_RS24330	2937072..2937656	-	585	WP_258469671.1	hypothetical protein	-
KZR01_RS24335	2937737..2937817	-	81	Protein_2726	DUF3265 domain-containing protein	-
KZR01_RS24340	2937831..2938205	-	375	WP_259556210.1	cysteine peptidase family C39 domain-containing protein	-
KZR01_RS24345	2938232..2938321	-	90	WP_259557769.1	DUF3265 domain-containing protein	-
KZR01_RS24350	2938401..2938685	+	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KZR01_RS24355	2938682..2938960	+	279	WP_065788201.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
KZR01_RS24360	2938989..2939078	-	90	WP_104027912.1	DUF3265 domain-containing protein	-
KZR01_RS24365	2939100..2939513	-	414	WP_114321754.1	RDD family protein	-
KZR01_RS24370	2939672..2940203	-	532	Protein_2733	GNAT family N-acetyltransferase	-
KZR01_RS24375	2940240..2940332	-	93	WP_004748931.1	DUF3265 domain-containing protein	-
KZR01_RS24380	2940347..2940856	-	510	WP_017188762.1	ClbS/DfsB family four-helix bundle protein	-
KZR01_RS24385	2940884..2941015	-	132	WP_081097936.1	DUF3265 domain-containing protein	-
KZR01_RS24390	2941550..2941621	-	72	Protein_2737	DUF3265 domain-containing protein	-
KZR01_RS24395	2941617..2942273	-	657	WP_259556211.1	hypothetical protein	-
KZR01_RS24400	2942336..2942425	-	90	WP_071881309.1	DUF3265 domain-containing protein	-
KZR01_RS24405	2942443..2942721	-	279	WP_038886177.1	hypothetical protein	-
KZR01_RS24410	2942866..2942934	-	69	Protein_2741	DUF3265 domain-containing protein	-
KZR01_RS24415	2942930..2943388	-	459	WP_259556212.1	GNAT family N-acetyltransferase	-
KZR01_RS24420	2943533..2943898	-	366	WP_005472418.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2862448..2962652	100204
	-	inside	Integron	-	-	2868257..2962652	94395

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10990.71 Da
• Isoelectric Point: 4.4558

>T210758 WP_065788201.1 NZ_CP080098:2938682-2938960 [Vibrio harveyi]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRRRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T210758 NZ_CP104613:c1096964-1096746 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11069.40 Da
• Isoelectric Point: 9.2167

>AT210758 WP_005398409.1 NZ_CP080098:2938401-2938685 [Vibrio harveyi]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT210758 NZ_CP104613:c1097364-1096990 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAACTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A347UR21