Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 2929622..2930171 Replicon chromosome
Accession NZ_CP080098
Organism Vibrio harveyi strain

Toxin (Protein)


Gene name parE Uniprot ID A0A2K7SRW8
Locus tag KZR01_RS24240 Protein ID WP_015296889.1
Coordinates 2929872..2930171 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A347UQT2
Locus tag KZR01_RS24235 Protein ID WP_005442033.1
Coordinates 2929622..2929864 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZR01_RS24195 2925036..2925125 - 90 WP_076665338.1 DUF3265 domain-containing protein -
KZR01_RS24200 2925154..2925498 - 345 WP_193303388.1 antibiotic biosynthesis monooxygenase -
KZR01_RS24205 2925718..2926239 - 522 WP_038881865.1 GNAT family N-acetyltransferase -
KZR01_RS24210 2926271..2926627 - 357 WP_259557763.1 DUF4238 domain-containing protein -
KZR01_RS24215 2926635..2927066 - 432 WP_259556202.1 hypothetical protein -
KZR01_RS24220 2927377..2927448 - 72 Protein_2703 DUF3265 domain-containing protein -
KZR01_RS24225 2927439..2927826 - 388 Protein_2704 NUDIX hydrolase -
KZR01_RS24230 2927945..2928811 - 867 WP_259556203.1 toll/interleukin-1 receptor domain-containing protein -
KZR01_RS24235 2929622..2929864 + 243 WP_005442033.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KZR01_RS24240 2929872..2930171 + 300 WP_015296889.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZR01_RS24245 2930235..2930327 - 93 WP_140263444.1 DUF3265 domain-containing protein -
KZR01_RS24250 2930342..2930860 - 519 WP_140263442.1 hypothetical protein -
KZR01_RS24255 2930997..2931541 - 545 Protein_2710 DinB family protein -
KZR01_RS24260 2931569..2931679 - 111 WP_259557755.1 DUF3265 domain-containing protein -
KZR01_RS24265 2931676..2932059 - 384 WP_238535117.1 hypothetical protein -
KZR01_RS24270 2932178..2932366 - 189 WP_259557765.1 DUF523 domain-containing protein -
KZR01_RS24275 2932323..2932667 - 345 WP_259556204.1 DUF523 domain-containing protein -
KZR01_RS24280 2932706..2932817 - 112 Protein_2715 DUF3265 domain-containing protein -
KZR01_RS24285 2932814..2933269 - 456 WP_038892793.1 NUDIX domain-containing protein -
KZR01_RS24290 2933322..2933414 - 93 WP_203343891.1 DUF3265 domain-containing protein -
KZR01_RS24295 2933487..2934494 - 1008 WP_259556205.1 hypothetical protein -
KZR01_RS24300 2934531..2934623 - 93 WP_259556206.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2862448..2962652 100204
- inside Integron - - 2868257..2962652 94395


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-55)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11502.11 Da        Isoelectric Point: 9.3224

>T210757 WP_015296889.1 NZ_CP080098:2929872-2930171 [Vibrio harveyi]
MQKNKYKLSNLAQSHLRKVKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDD
FILVVAVLGQSQLPQNHLK

Download         Length: 300 bp

>T210757 NZ_CP104613:c844273-843995 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATATTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGCTCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9047.26 Da        Isoelectric Point: 5.6926

>AT210757 WP_005442033.1 NZ_CP080098:2929622-2929864 [Vibrio harveyi]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Download         Length: 243 bp

>AT210757 NZ_CP104613:c844536-844276 [Escherichia coli]
ATGGCTGCAAATGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGGTGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K7SRW8

Antitoxin

Source ID Structure
AlphaFold DB A0A347UQT2

References