Detailed information of TA system TA210756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2915520..2916048
• Replicon: chromosome
• Accession: NZ_CP080098
• Organism: Vibrio harveyi strain

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KZR01_RS24080
• Protein ID: WP_259556197.1
• Coordinates: 2915520..2915807 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4Y8W958
• Locus tag: KZR01_RS24085
• Protein ID: WP_017038856.1
• Coordinates: 2915797..2916048 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZR01_RS24015	2911063..2911668	-	606	WP_259556192.1	hypothetical protein	-
KZR01_RS24020	2911713..2911804	-	92	Protein_2663	DUF3265 domain-containing protein	-
KZR01_RS24025	2911881..2912165	+	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
KZR01_RS24030	2912162..2912440	+	279	WP_259556193.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KZR01_RS24035	2912514..2912585	-	72	Protein_2666	DUF3265 domain-containing protein	-
KZR01_RS24040	2912817..2913281	-	465	WP_259556194.1	hypothetical protein	-
KZR01_RS24045	2913309..2913419	-	111	WP_259557749.1	DUF3265 domain-containing protein	-
KZR01_RS24050	2913416..2913637	-	222	WP_259556195.1	hypothetical protein	-
KZR01_RS24055	2913786..2913875	-	90	WP_080261741.1	DUF3265 domain-containing protein	-
KZR01_RS24060	2913893..2914438	-	546	WP_259557826.1	hypothetical protein	-
KZR01_RS24065	2914466..2914558	-	93	WP_259556196.1	DUF3265 domain-containing protein	-
KZR01_RS24070	2914587..2914961	-	375	WP_095760849.1	hypothetical protein	-
KZR01_RS24075	2915054..2915140	-	87	Protein_2674	DUF3265 domain-containing protein	-
KZR01_RS24080	2915520..2915807	-	288	WP_259556197.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZR01_RS24085	2915797..2916048	-	252	WP_017038856.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KZR01_RS24090	2916140..2916269	-	130	Protein_2677	DUF3265 domain-containing protein	-
KZR01_RS24095	2916690..2916819	-	130	Protein_2678	DUF3265 domain-containing protein	-
KZR01_RS24100	2917239..2917331	-	93	WP_079740779.1	DUF3265 domain-containing protein	-
KZR01_RS24105	2917347..2917988	-	642	WP_140122975.1	hypothetical protein	-
KZR01_RS24110	2918023..2918115	-	93	Protein_2681	DUF3265 domain-containing protein	-
KZR01_RS24115	2918241..2918543	+	303	WP_061065142.1	hypothetical protein	-
KZR01_RS24120	2918752..2919295	-	544	Protein_2683	DinB family protein	-
KZR01_RS24125	2919432..2919779	-	348	WP_259556198.1	hypothetical protein	-
KZR01_RS24130	2919946..2920413	-	468	WP_228772204.1	DUF4476 domain-containing protein	-
KZR01_RS24135	2920454..2920543	-	90	WP_259557753.1	DUF3265 domain-containing protein	-
KZR01_RS24140	2920561..2921037	-	477	WP_080532940.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2862448..2962652	100204
	-	inside	Integron	-	-	2868257..2962652	94395

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-70)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11073.03 Da
• Isoelectric Point: 10.4934

>T210756 WP_259556197.1 NZ_CP080098:c2915807-2915520 [Vibrio harveyi]
MTYKLKFLPAAHKEWSKLAPPIQSQFKKKLKERLENPHVPSSKLRGYDSVYKIKLRTAGYRLAYEVIDDEIVVYVLAIGK
RDKDAVYKKLASRFS

Nucleotide

• Length: 288 bp

>T210756 NZ_CP104613:609637-609951 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTATCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.34 Da
• Isoelectric Point: 3.9840

>AT210756 WP_017038856.1 NZ_CP080098:c2916048-2915797 [Vibrio harveyi]
MRQVLADCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEFLMDMLDDYELAKLVESRRGELSEAVEVDI
DDL

Nucleotide

• Length: 252 bp

>AT210756 NZ_CP104613:609401-609634 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Antitoxin

• AlphaFold DB: A0A4Y8W958