Detailed information of TA system TA210755

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2911881..2912440
• Replicon: chromosome
• Accession: NZ_CP080098
• Organism: Vibrio harveyi strain

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KZR01_RS24030
• Protein ID: WP_259556193.1
• Coordinates: 2912162..2912440 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR21
• Locus tag: KZR01_RS24025
• Protein ID: WP_005398409.1
• Coordinates: 2911881..2912165 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZR01_RS23975	2907546..2907611	-	66	Protein_2654	DUF3265 domain-containing protein	-
KZR01_RS23980	2907608..2908267	-	660	WP_061065161.1	hypothetical protein	-
KZR01_RS23985	2908634..2909161	+	528	WP_206666879.1	hypothetical protein	-
KZR01_RS23990	2909267..2909329	-	63	Protein_2657	DUF3265 domain-containing protein	-
KZR01_RS23995	2909329..2909607	-	279	WP_259556191.1	hypothetical protein	-
KZR01_RS24000	2909733..2909825	-	93	WP_080338837.1	DUF3265 domain-containing protein	-
KZR01_RS24005	2909853..2910140	-	288	WP_005445239.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KZR01_RS24010	2910137..2910418	-	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
KZR01_RS24015	2911063..2911668	-	606	WP_259556192.1	hypothetical protein	-
KZR01_RS24020	2911713..2911804	-	92	Protein_2663	DUF3265 domain-containing protein	-
KZR01_RS24025	2911881..2912165	+	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KZR01_RS24030	2912162..2912440	+	279	WP_259556193.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZR01_RS24035	2912514..2912585	-	72	Protein_2666	DUF3265 domain-containing protein	-
KZR01_RS24040	2912817..2913281	-	465	WP_259556194.1	hypothetical protein	-
KZR01_RS24045	2913309..2913419	-	111	WP_259557749.1	DUF3265 domain-containing protein	-
KZR01_RS24050	2913416..2913637	-	222	WP_259556195.1	hypothetical protein	-
KZR01_RS24055	2913786..2913875	-	90	WP_080261741.1	DUF3265 domain-containing protein	-
KZR01_RS24060	2913893..2914438	-	546	WP_259557826.1	hypothetical protein	-
KZR01_RS24065	2914466..2914558	-	93	WP_259556196.1	DUF3265 domain-containing protein	-
KZR01_RS24070	2914587..2914961	-	375	WP_095760849.1	hypothetical protein	-
KZR01_RS24075	2915054..2915140	-	87	Protein_2674	DUF3265 domain-containing protein	-
KZR01_RS24080	2915520..2915807	-	288	WP_259556197.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KZR01_RS24085	2915797..2916048	-	252	WP_017038856.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
KZR01_RS24090	2916140..2916269	-	130	Protein_2677	DUF3265 domain-containing protein	-
KZR01_RS24095	2916690..2916819	-	130	Protein_2678	DUF3265 domain-containing protein	-
KZR01_RS24100	2917239..2917331	-	93	WP_079740779.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2862448..2962652	100204
	-	inside	Integron	-	-	2868257..2962652	94395

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10891.57 Da
• Isoelectric Point: 4.3430

>T210755 WP_259556193.1 NZ_CP080098:2912162-2912440 [Vibrio harveyi]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDVIRVM
RILHQKQKFPTD

Nucleotide

• Length: 279 bp

>T210755 NZ_CP104613:492218-492505 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTCACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11069.40 Da
• Isoelectric Point: 9.2167

>AT210755 WP_005398409.1 NZ_CP080098:2911881-2912165 [Vibrio harveyi]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT210755 NZ_CP104613:492492-492794 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAATAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A347UR21