Detailed information of TA system TA210754

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 2909853..2910418
• Replicon: chromosome
• Accession: NZ_CP080098
• Organism: Vibrio harveyi strain

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A916ASF8
• Locus tag: KZR01_RS24005
• Protein ID: WP_005445239.1
• Coordinates: 2909853..2910140 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: KZR01_RS24010
• Protein ID: WP_000086647.1
• Coordinates: 2910137..2910418 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZR01_RS23960	2905452..2905874	-	423	WP_259556190.1	hypothetical protein	-
KZR01_RS23965	2906239..2906331	-	93	WP_259557741.1	DUF3265 domain-containing protein	-
KZR01_RS23970	2906871..2906960	-	90	WP_079765356.1	DUF3265 domain-containing protein	-
KZR01_RS23975	2907546..2907611	-	66	Protein_2654	DUF3265 domain-containing protein	-
KZR01_RS23980	2907608..2908267	-	660	WP_061065161.1	hypothetical protein	-
KZR01_RS23985	2908634..2909161	+	528	WP_206666879.1	hypothetical protein	-
KZR01_RS23990	2909267..2909329	-	63	Protein_2657	DUF3265 domain-containing protein	-
KZR01_RS23995	2909329..2909607	-	279	WP_259556191.1	hypothetical protein	-
KZR01_RS24000	2909733..2909825	-	93	WP_080338837.1	DUF3265 domain-containing protein	-
KZR01_RS24005	2909853..2910140	-	288	WP_005445239.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZR01_RS24010	2910137..2910418	-	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KZR01_RS24015	2911063..2911668	-	606	WP_259556192.1	hypothetical protein	-
KZR01_RS24020	2911713..2911804	-	92	Protein_2663	DUF3265 domain-containing protein	-
KZR01_RS24025	2911881..2912165	+	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
KZR01_RS24030	2912162..2912440	+	279	WP_259556193.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KZR01_RS24035	2912514..2912585	-	72	Protein_2666	DUF3265 domain-containing protein	-
KZR01_RS24040	2912817..2913281	-	465	WP_259556194.1	hypothetical protein	-
KZR01_RS24045	2913309..2913419	-	111	WP_259557749.1	DUF3265 domain-containing protein	-
KZR01_RS24050	2913416..2913637	-	222	WP_259556195.1	hypothetical protein	-
KZR01_RS24055	2913786..2913875	-	90	WP_080261741.1	DUF3265 domain-containing protein	-
KZR01_RS24060	2913893..2914438	-	546	WP_259557826.1	hypothetical protein	-
KZR01_RS24065	2914466..2914558	-	93	WP_259556196.1	DUF3265 domain-containing protein	-
KZR01_RS24070	2914587..2914961	-	375	WP_095760849.1	hypothetical protein	-
KZR01_RS24075	2915054..2915140	-	87	Protein_2674	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2862448..2962652	100204
	-	inside	Integron	-	-	2868257..2962652	94395

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11031.70 Da
• Isoelectric Point: 5.1098

>T210754 WP_005445239.1 NZ_CP080098:c2910140-2909853 [Vibrio harveyi]
MKVVWSPLALQKLGDAAEFISLDNPPAAERWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Nucleotide

• Length: 288 bp

>T210754 NZ_CP104613:444478-444855 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT210754 WP_000086647.1 NZ_CP080098:c2910418-2910137 [Vibrio harveyi]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT210754 NZ_CP104613:444057-444431 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCAGATGCATACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAATCACCTCATAA

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0