Detailed information of TA system TA210752

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2875739..2876298
• Replicon: chromosome
• Accession: NZ_CP080098
• Organism: Vibrio harveyi strain

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A2K7SRU8
• Locus tag: KZR01_RS23665
• Protein ID: WP_017035198.1
• Coordinates: 2876020..2876298 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KZR01_RS23660
• Protein ID: WP_259556166.1
• Coordinates: 2875739..2876023 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZR01_RS23625	2870879..2870971	-	93	WP_080259420.1	DUF3265 domain-containing protein	-
KZR01_RS23630	2872516..2872605	-	90	WP_079883834.1	DUF3265 domain-containing protein	-
KZR01_RS23635	2873736..2874020	-	285	WP_259556165.1	hypothetical protein	-
KZR01_RS23640	2874370..2874459	-	90	WP_071881309.1	DUF3265 domain-containing protein	-
KZR01_RS23645	2874489..2874965	-	477	WP_045596098.1	GNAT family N-acetyltransferase	-
KZR01_RS23650	2875037..2875102	-	66	Protein_2589	DUF3265 domain-containing protein	-
KZR01_RS23655	2875099..2875542	-	444	WP_259557717.1	GNAT family N-acetyltransferase	-
KZR01_RS23660	2875739..2876023	+	285	WP_259556166.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KZR01_RS23665	2876020..2876298	+	279	WP_017035198.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
KZR01_RS23670	2876327..2876419	-	93	WP_196333304.1	DUF3265 domain-containing protein	-
KZR01_RS23675	2876445..2877005	-	561	WP_058666954.1	hypothetical protein	-
KZR01_RS23680	2877247..2877651	-	405	WP_259556167.1	hypothetical protein	-
KZR01_RS23685	2877831..2878187	-	357	WP_259556168.1	DUF5675 family protein	-
KZR01_RS23690	2878457..2878990	-	534	WP_259556169.1	cysteine hydrolase family protein	-
KZR01_RS23695	2879226..2880389	+	1164	WP_081097942.1	PAAR domain-containing protein	-
KZR01_RS23700	2880386..2880895	+	510	WP_053053932.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2862448..2962652	100204
	-	inside	Integron	-	-	2868257..2962652	94395

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10905.60 Da
• Isoelectric Point: 4.3430

>T210752 WP_017035198.1 NZ_CP080098:2876020-2876298 [Vibrio harveyi]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWIEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T210752 NZ_CP104609:2729-2977 [Klebsiella pneumoniae]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11053.36 Da
• Isoelectric Point: 9.2167

>AT210752 WP_259556166.1 NZ_CP080098:2875739-2876023 [Vibrio harveyi]
MDTRIQFRVDEETKRPAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT210752 NZ_CP104609:2974-3321 [Klebsiella pneumoniae]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A2K7SRU8