Detailed information of TA system TA210751

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2867967..2868514
• Replicon: chromosome
• Accession: NZ_CP080098
• Organism: Vibrio harveyi strain

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A454B353
• Locus tag: KZR01_RS23590
• Protein ID: WP_005445657.1
• Coordinates: 2867967..2868269 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A454B3H2
• Locus tag: KZR01_RS23595
• Protein ID: WP_005445660.1
• Coordinates: 2868257..2868514 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZR01_RS23550	2863543..2863788	-	246	WP_123947168.1	hypothetical protein	-
KZR01_RS23555	2864100..2864390	-	291	WP_017190343.1	hypothetical protein	-
KZR01_RS23560	2864453..2864704	-	252	WP_005445646.1	DUF2442 domain-containing protein	-
KZR01_RS23565	2865951..2866382	-	432	WP_005445651.1	GNAT family N-acetyltransferase	-
KZR01_RS23570	2866591..2867007	-	417	WP_005445653.1	hypothetical protein	-
KZR01_RS23575	2867083..2867193	-	111	Protein_2574	DUF3265 domain-containing protein	-
KZR01_RS23580	2867248..2867442	-	195	WP_061065127.1	hypothetical protein	-
KZR01_RS23585	2867771..2867923	+	153	Protein_2576	IS30 family transposase	-
KZR01_RS23590	2867967..2868269	-	303	WP_005445657.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZR01_RS23595	2868257..2868514	-	258	WP_005445660.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KZR01_RS23600	2868596..2868673	-	78	WP_226982105.1	DUF3265 domain-containing protein	-
KZR01_RS23605	2868725..2869336	-	612	WP_259556162.1	hypothetical protein	-
KZR01_RS23610	2869545..2869637	-	93	WP_220456997.1	DUF3265 domain-containing protein	-
KZR01_RS23615	2869652..2870161	-	510	WP_259556163.1	hypothetical protein	-
KZR01_RS23620	2870255..2870386	-	132	WP_259556164.1	DUF3265 domain-containing protein	-
KZR01_RS23625	2870879..2870971	-	93	WP_080259420.1	DUF3265 domain-containing protein	-
KZR01_RS23630	2872516..2872605	-	90	WP_079883834.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2862448..2962652	100204
	-	inside	Integron	-	-	2868257..2962652	94395

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11681.63 Da
• Isoelectric Point: 6.9800

>T210751 WP_005445657.1 NZ_CP080098:c2868269-2867967 [Vibrio harveyi]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPDLKHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLNKQ

Nucleotide

• Length: 303 bp

>T210751 NZ_CP104609:765-1016 [Klebsiella pneumoniae]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCTGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9548.06 Da
• Isoelectric Point: 7.3177

>AT210751 WP_005445660.1 NZ_CP080098:c2868514-2868257 [Vibrio harveyi]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKGKM
SKWLK

Nucleotide

• Length: 258 bp

>AT210751 NZ_CP104609:1003-1230 [Klebsiella pneumoniae]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Structures

Toxin

• AlphaFold DB: A0A454B353

Antitoxin

• AlphaFold DB: A0A454B3H2