Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3273608..3274257 Replicon chromosome
Accession NZ_CP080095
Organism Paraburkholderia edwinii strain Pe01

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KZJ38_RS14450 Protein ID WP_219796622.1
Coordinates 3274075..3274257 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KZJ38_RS14445 Protein ID WP_219796620.1
Coordinates 3273608..3274009 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZJ38_RS14420 (KZJ38_14420) 3269062..3269409 - 348 Protein_2825 cupin domain-containing protein -
KZJ38_RS14425 (KZJ38_14425) 3269426..3270826 - 1401 WP_219796613.1 FAD-containing oxidoreductase -
KZJ38_RS14430 (KZJ38_14430) 3271064..3271270 - 207 WP_219796615.1 hypothetical protein -
KZJ38_RS14435 (KZJ38_14435) 3271500..3272129 - 630 WP_219796617.1 glutathione S-transferase -
KZJ38_RS14440 (KZJ38_14440) 3272345..3273448 - 1104 WP_219796619.1 hypothetical protein -
KZJ38_RS14445 (KZJ38_14445) 3273608..3274009 - 402 WP_219796620.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KZJ38_RS14450 (KZJ38_14450) 3274075..3274257 - 183 WP_219796622.1 type II toxin-antitoxin system HicA family toxin Toxin
KZJ38_RS14455 (KZJ38_14455) 3274951..3276090 + 1140 WP_219796624.1 LacI family DNA-binding transcriptional regulator -
KZJ38_RS14460 (KZJ38_14460) 3276391..3277392 + 1002 WP_246641773.1 ABC transporter substrate-binding protein -
KZJ38_RS14465 (KZJ38_14465) 3277389..3278213 + 825 WP_219796626.1 ABC transporter permease -
KZJ38_RS14470 (KZJ38_14470) 3278246..3279256 + 1011 WP_246641477.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6681.79 Da        Isoelectric Point: 11.3688

>T210750 WP_219796622.1 NZ_CP080095:c3274257-3274075 [Paraburkholderia edwinii]
MNSSQLIRMLEEDGWRLVRVTGSHHHFKHTGKRGLVTVPHPKKDLPIGTSKSILKAAGLN

Download         Length: 183 bp

>T210750 NZ_CP104608:11350-11766 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14452.38 Da        Isoelectric Point: 4.6329

>AT210750 WP_219796620.1 NZ_CP080095:c3274009-3273608 [Paraburkholderia edwinii]
MEFPIAVHKDDGSAYGVIVPDIPGVHSWGDTIDDAIRNTKEAIVGHVSTLVELGEDVGFTCSTVEELVAKPEYVGAVWAL
VDVDLTQLDSKPERINVSLPRFVLRKIDAYVTARHETRSGFLARAALEALAHA

Download         Length: 402 bp

>AT210750 NZ_CP104608:11123-11353 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References