Detailed information of TA system TA021075

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 2332401..2332985
• Replicon: chromosome
• Accession: NC_006138
• Organism: Desulfotalea psychrophila LSv54

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DP_RS10535
• Protein ID: WP_041278679.1
• Coordinates: 2332401..2332697 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q6ALJ0
• Locus tag: DP_RS10540
• Protein ID: WP_011189297.1
• Coordinates: 2332710..2332985 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DP_RS18365	2328235..2328648	+	414	WP_011189290.1	hypothetical protein	-
DP_RS18370	2328629..2329339	+	711	WP_011189291.1	nucleotide-binding protein	-
DP_RS10510	2329690..2330085	+	396	WP_011189292.1	hypothetical protein	-
DP_RS10515	2330207..2330632	+	426	WP_011189293.1	hypothetical protein	-
DP_RS10520	2330650..2330904	+	255	WP_011189294.1	carboxymuconolactone decarboxylase family protein	-
DP_RS10525	2331706..2332086	-	381	WP_041277895.1	hypothetical protein	-
DP_RS10535	2332401..2332697	+	297	WP_041278679.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DP_RS10540	2332710..2332985	+	276	WP_011189297.1	putative addiction module antidote protein	Antitoxin
DP_RS10550	2333646..2334281	+	636	WP_011189299.1	chloramphenicol acetyltransferase	-
DP_RS18210	2334471..2334770	-	300	WP_011189300.1	hypothetical protein	-
DP_RS10560	2335672..2335953	-	282	WP_041277898.1	hypothetical protein	-
DP_RS10565	2335950..2337113	-	1164	WP_041277899.1	APC family permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2323561..2334281	10720

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-85)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11604.72 Da
• Isoelectric Point: 10.4154

>T21075 WP_041278679.1 NC_006138:2332401-2332697 [Desulfotalea psychrophila LSv54]
MEYEIDRTKKFDKWLKKLKETEAKLTILARIDRVKIGHFGDQKQLEENFFEIRLFTGPGYRIYYTIRGGKIVLLLLAGDK
SSQKKDIKKAKELIKKLE

Nucleotide

• Length: 297 bp

>T21075 NC_006138:2332401-2332697 [Desulfotalea psychrophila LSv54]
ATGGAGTATGAAATTGATCGTACAAAAAAATTTGATAAGTGGCTGAAAAAGCTTAAAGAAACTGAAGCTAAACTCACTAT
CCTTGCAAGGATAGACAGAGTGAAGATTGGTCATTTCGGTGACCAAAAACAGCTTGAAGAAAATTTTTTCGAAATCCGTC
TTTTTACAGGCCCAGGCTATAGAATCTATTACACCATCAGAGGTGGCAAGATTGTTTTGTTGCTTTTGGCAGGTGATAAA
AGTAGCCAGAAAAAAGATATAAAGAAGGCCAAAGAGCTTATTAAAAAGCTTGAATAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10283.80 Da
• Isoelectric Point: 10.3026

>AT21075 WP_011189297.1 NC_006138:2332710-2332985 [Desulfotalea psychrophila LSv54]
MAKTASYNPFDYLTTEEEIRTYLDNASRDEDPRIFVIALGYLAKKRGMKATAKKVGVSRESLYKSLSGKGNPKYDTIRKV
TQALGYQARVK

Nucleotide

• Length: 276 bp

>AT21075 NC_006138:2332710-2332985 [Desulfotalea psychrophila LSv54]
ATGGCTAAAACAGCTTCCTACAATCCATTTGACTATCTCACCACAGAAGAAGAGATACGAACATACCTTGATAATGCCTC
CAGAGATGAAGACCCAAGAATTTTTGTTATAGCTCTTGGCTATCTGGCAAAAAAACGTGGCATGAAAGCAACCGCTAAAA
AAGTTGGTGTAAGCCGTGAGAGTCTTTACAAATCTCTTTCTGGAAAAGGTAACCCAAAATATGACACAATCCGCAAAGTG
ACCCAAGCGCTGGGCTACCAAGCACGGGTAAAGTGA

Structures

Antitoxin

• AlphaFold DB: Q6ALJ0