Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2948766..2949411 Replicon chromosome
Accession NZ_CP080095
Organism Paraburkholderia edwinii strain Pe01

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KZJ38_RS13015 Protein ID WP_219796287.1
Coordinates 2948766..2949185 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KZJ38_RS13020 Protein ID WP_219796288.1
Coordinates 2949172..2949411 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZJ38_RS12995 (KZJ38_12995) 2943967..2945562 - 1596 WP_219796284.1 sugar ABC transporter ATP-binding protein -
KZJ38_RS13000 (KZJ38_13000) 2945910..2946866 - 957 WP_219796285.1 sugar ABC transporter substrate-binding protein -
KZJ38_RS13005 (KZJ38_13005) 2947097..2948074 - 978 WP_219796286.1 magnesium/cobalt transporter CorA -
KZJ38_RS13010 (KZJ38_13010) 2948138..2948656 - 519 WP_246641462.1 hypothetical protein -
KZJ38_RS13015 (KZJ38_13015) 2948766..2949185 - 420 WP_219796287.1 type II toxin-antitoxin system VapC family toxin Toxin
KZJ38_RS13020 (KZJ38_13020) 2949172..2949411 - 240 WP_219796288.1 DNA-binding protein Antitoxin
KZJ38_RS13025 (KZJ38_13025) 2949708..2949881 + 174 WP_219796289.1 cytochrome bd-I oxidase subunit CydX -
KZJ38_RS13030 (KZJ38_13030) 2950183..2951280 - 1098 WP_219796290.1 saccharopine dehydrogenase C-terminal domain-containing protein -
KZJ38_RS13035 (KZJ38_13035) 2951515..2951988 - 474 WP_219796291.1 Lrp/AsnC family transcriptional regulator -
KZJ38_RS13040 (KZJ38_13040) 2952123..2952665 - 543 WP_219796292.1 RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15498.57 Da        Isoelectric Point: 6.3322

>T210749 WP_219796287.1 NZ_CP080095:c2949185-2948766 [Paraburkholderia edwinii]
VYLIDTNVISEIRKQRGADEGVREFFSHAQKEQLGLYLSVITIGELRRGVDLMRHRGDVEQATKLEEWLNTLLGTFANHI
LTVGDDVAQTWGRLRVPHAEHSLDKLIAATALIYNLTVVTRNTDDFAGTGARVINPFGA

Download         Length: 420 bp

>T210749 NZ_CP104607:14235-14540 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8894.09 Da        Isoelectric Point: 5.1584

>AT210749 WP_219796288.1 NZ_CP080095:c2949411-2949172 [Paraburkholderia edwinii]
MPTLLVRGLEEALVECLRKRAASNNRSVEAEHREILAEALRHPKKLSFAQVLMSMPDVGKDADFERVNNDEGEGSRVFD

Download         Length: 240 bp

>AT210749 NZ_CP104607:14015-14233 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References