Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/MqsA(antitoxin) |
| Location | 18954..19419 | Replicon | plasmid pS8245-3 |
| Accession | NZ_CP080094 | ||
| Organism | Salmonella enterica strain SLR1_8245 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | U9ZUY2 |
| Locus tag | KZY40_RS23490 | Protein ID | WP_001230707.1 |
| Coordinates | 19168..19419 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | M7CCF8 |
| Locus tag | KZY40_RS23485 | Protein ID | WP_000801440.1 |
| Coordinates | 18954..19181 (-) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KZY40_RS23445 (KZY40_23445) | 14184..14399 | - | 216 | WP_000760375.1 | EexN family lipoprotein | - |
| KZY40_RS23450 (KZY40_23450) | 14396..14689 | - | 294 | WP_060598542.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
| KZY40_RS23455 (KZY40_23455) | 14766..15995 | - | 1230 | WP_001329504.1 | DNA relaxase/nickase TaxC | - |
| KZY40_RS23460 (KZY40_23460) | 15999..16502 | - | 504 | WP_000781813.1 | relaxosome-coupling protein TaxA | - |
| KZY40_RS23465 (KZY40_23465) | 16863..17210 | - | 348 | WP_000681613.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| KZY40_RS23470 (KZY40_23470) | 17207..17455 | - | 249 | WP_000520549.1 | type II toxin-antitoxin system HicA family toxin | - |
| KZY40_RS23475 (KZY40_23475) | 17760..18110 | - | 351 | WP_000854259.1 | hypothetical protein | - |
| KZY40_RS23480 (KZY40_23480) | 18201..18500 | - | 300 | WP_000650309.1 | hypothetical protein | - |
| KZY40_RS23485 (KZY40_23485) | 18954..19181 | - | 228 | WP_000801440.1 | hypothetical protein | Antitoxin |
| KZY40_RS23490 (KZY40_23490) | 19168..19419 | - | 252 | WP_001230707.1 | hypothetical protein | Toxin |
| KZY40_RS23495 (KZY40_23495) | 19416..19958 | - | 543 | WP_001083906.1 | hypothetical protein | - |
| KZY40_RS23500 (KZY40_23500) | 20063..20578 | - | 516 | Protein_26 | DnaJ domain-containing protein | - |
| KZY40_RS23505 (KZY40_23505) | 21993..22859 | + | 867 | WP_001353743.1 | replication initiation protein | - |
| KZY40_RS23510 (KZY40_23510) | 22872..23276 | + | 405 | WP_012421203.1 | hypothetical protein | - |
| KZY40_RS23515 (KZY40_23515) | 23411..23938 | + | 528 | WP_000577043.1 | DUF2726 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | mcr-1.1 | - | 1..33310 | 33310 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9751.13 Da Isoelectric Point: 8.9187
>T210747 WP_001230707.1 NZ_CP080094:c19419-19168 [Salmonella enterica]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR
Download Length: 252 bp
>T210747 NZ_CP104605:c154430-154119 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8659.98 Da Isoelectric Point: 8.5105
>AT210747 WP_000801440.1 NZ_CP080094:c19181-18954 [Salmonella enterica]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK
Download Length: 228 bp
>AT210747 NZ_CP104605:c154122-153703 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U9ZUY2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Y6U8W9 |