Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 20318..20840 Replicon plasmid pS8245-2
Accession NZ_CP080093
Organism Salmonella enterica strain SLR1_8245

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag KZY40_RS23185 Protein ID WP_000220561.1
Coordinates 20318..20599 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag KZY40_RS23190 Protein ID WP_000121743.1
Coordinates 20589..20840 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY40_RS23135 (KZY40_23135) 16163..17329 - 1167 WP_052909232.1 MobP1 family relaxase -
KZY40_RS23140 (KZY40_23140) 17332..17877 - 546 WP_000757693.1 DNA distortion polypeptide 1 -
KZY40_RS23150 (KZY40_23150) 18203..18475 - 273 WP_000160399.1 hypothetical protein -
KZY40_RS23155 (KZY40_23155) 18488..18637 - 150 WP_000003880.1 hypothetical protein -
KZY40_RS23160 (KZY40_23160) 18707..18886 - 180 WP_072104066.1 hypothetical protein -
KZY40_RS23165 (KZY40_23165) 18929..19258 - 330 WP_000866648.1 hypothetical protein -
KZY40_RS23170 (KZY40_23170) 19351..19566 - 216 WP_001180116.1 hypothetical protein -
KZY40_RS23175 (KZY40_23175) 19556..19801 - 246 WP_052909233.1 hypothetical protein -
KZY40_RS23180 (KZY40_23180) 19849..20172 - 324 WP_001181905.1 hypothetical protein -
KZY40_RS23185 (KZY40_23185) 20318..20599 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZY40_RS23190 (KZY40_23190) 20589..20840 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
KZY40_RS23195 (KZY40_23195) 22075..22914 + 840 WP_001352874.1 replication initiation protein -
KZY40_RS23200 (KZY40_23200) 22935..23777 + 843 WP_116838170.1 replication initiation protein -
KZY40_RS23205 (KZY40_23205) 23781..24224 + 444 WP_001074379.1 hypothetical protein -
KZY40_RS23210 (KZY40_23210) 24364..24720 + 357 WP_001546351.1 DNA distortion polypeptide 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / catA1 - 1..56813 56813


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11023.86 Da        Isoelectric Point: 10.5938

>T210745 WP_000220561.1 NZ_CP080093:c20599-20318 [Salmonella enterica]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

>T210745 NZ_CP104605:54909-55379 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT210745 WP_000121743.1 NZ_CP080093:c20840-20589 [Salmonella enterica]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT210745 NZ_CP104605:54469-54912 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAAGTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACTGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References