Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4179838..4180619 Replicon chromosome
Accession NZ_CP080091
Organism Salmonella enterica strain SLR1_8245

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag KZY40_RS20365 Protein ID WP_000626100.1
Coordinates 4179838..4180329 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag KZY40_RS20370 Protein ID WP_001110452.1
Coordinates 4180326..4180619 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY40_RS20330 (4175298) 4175298..4175645 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
KZY40_RS20335 (4175621) 4175621..4177324 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
KZY40_RS20340 (4177361) 4177361..4177936 + 576 WP_001188509.1 transcriptional regulator -
KZY40_RS20350 (4178207) 4178207..4178281 - 75 Protein_3995 helix-turn-helix domain-containing protein -
KZY40_RS20355 (4178661) 4178661..4178738 + 78 Protein_3996 porin family protein -
KZY40_RS20360 (4178838) 4178838..4179590 + 753 WP_000842433.1 non-specific acid phosphatase -
KZY40_RS20365 (4179838) 4179838..4180329 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
KZY40_RS20370 (4180326) 4180326..4180619 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
KZY40_RS20375 (4180936) 4180936..4181157 + 222 WP_001576552.1 hypothetical protein -
KZY40_RS20380 (4181423) 4181423..4182298 + 876 WP_000921676.1 AraC family transcriptional regulator -
KZY40_RS20385 (4182295) 4182295..4182582 + 288 WP_001541332.1 transcriptional regulator RtsB -
KZY40_RS20390 (4182575) 4182575..4182883 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
KZY40_RS20395 (4182882) 4182882..4183130 + 249 Protein_4004 Ig-like domain-containing protein -
KZY40_RS23800 (4183242) 4183242..4183373 + 132 Protein_4005 hypothetical protein -
KZY40_RS20400 (4183667) 4183667..4184572 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T210742 WP_000626100.1 NZ_CP080091:c4180329-4179838 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T210742 NZ_CP104604:104231-104647 [Klebsiella pneumoniae]
GTGATTAAAACCTATATGCTGGACACTAACATTTGCTCGTTCATCATGCGTGAGCAGCCGGAAGCTGTCATTAAACGACT
GGAACAGGCAGTGCTGCGCAATCACCGCATTGTGGTTTCGGCCATCACTTATGCTGAGATGCGTTTCGGTGCAATCGGAA
AGAAGGCATCCCCTCGCCACGGCCTGCTTGTCGAAGCTTTCTGCGCCCGTCTCGATGCAATCCTCGCCTGGGACCGCGCA
GCGGTGGACGCAAGCACGGAGATTAAGGCTGCGTTGACTGCAGCCGGTACACCTATCGGTCCCAACGACACAGCGATTGC
CGGGCATGCTATCGCCGCTGGCGCCGTGCTGGTGACGAACAATGTGCGTGAGTTTGAACGTGTGCCCGGCCTGGTCCTGG
AAGACTGGGCTAGCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT210742 WP_001110452.1 NZ_CP080091:c4180619-4180326 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT210742 NZ_CP104604:104004-104234 [Klebsiella pneumoniae]
ATGAGAACCGTATCGATATTCAAGAATGGCAACAATCGCGCCATCCGTCTGCCCCGTGACCTGGATTTTGAAGGAGTGAG
TGAACTGGAAATCGTCCGTGAAGGTGACAGCATCATCCTTCGTCCCGTTCGCCCAACATGGGGTTCGTTTACTCAGCTCG
AAAATGCTGATCCGGACTTTATGGCCGAGCGTGGTGATGTTGTCAGCGATGAAGGACGGTTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References