Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4072951..4073467 Replicon chromosome
Accession NZ_CP080091
Organism Salmonella enterica strain SLR1_8245

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag KZY40_RS19795 Protein ID WP_000220582.1
Coordinates 4072951..4073235 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag KZY40_RS19800 Protein ID WP_000212724.1
Coordinates 4073225..4073467 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY40_RS19780 (4068162) 4068162..4069814 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
KZY40_RS19785 (4070223) 4070223..4072361 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
KZY40_RS19790 (4072483) 4072483..4072947 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KZY40_RS19795 (4072951) 4072951..4073235 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZY40_RS19800 (4073225) 4073225..4073467 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KZY40_RS19805 (4073545) 4073545..4075458 - 1914 WP_001212142.1 BglG family transcription antiterminator -
KZY40_RS19810 (4075475) 4075475..4076215 - 741 WP_000779259.1 KDGP aldolase family protein -
KZY40_RS19815 (4076212) 4076212..4077330 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
KZY40_RS19820 (4077314) 4077314..4078447 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T210741 WP_000220582.1 NZ_CP080091:c4073235-4072951 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T210741 NZ_CP104604:38056-38526 [Klebsiella pneumoniae]
GTGATCTTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT210741 WP_000212724.1 NZ_CP080091:c4073467-4073225 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT210741 NZ_CP104604:37616-38059 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References