Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4031826..4032376 Replicon chromosome
Accession NZ_CP080091
Organism Salmonella enterica strain SLR1_8245

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag KZY40_RS19585 Protein ID WP_001199743.1
Coordinates 4031826..4032134 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag KZY40_RS19590 Protein ID WP_001118105.1
Coordinates 4032137..4032376 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZY40_RS19565 (4028400) 4028400..4029140 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
KZY40_RS19570 (4029262) 4029262..4029792 - 531 WP_000909461.1 SEF14 fimbria major subunit SefA -
KZY40_RS19575 (4030115) 4030115..4031248 + 1134 Protein_3844 IS3 family transposase -
KZY40_RS19580 (4031280) 4031280..4031420 - 141 Protein_3845 Arm DNA-binding domain-containing protein -
KZY40_RS19585 (4031826) 4031826..4032134 - 309 WP_001199743.1 CcdB family protein Toxin
KZY40_RS19590 (4032137) 4032137..4032376 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
KZY40_RS19595 (4032485) 4032485..4032733 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
KZY40_RS19600 (4032924) 4032924..4033355 - 432 Protein_3849 helix-turn-helix domain-containing protein -
KZY40_RS19610 (4034112) 4034112..4035131 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
KZY40_RS19615 (4035159) 4035159..4035689 - 531 WP_000896758.1 gluconokinase -
KZY40_RS19620 (4035906) 4035906..4036937 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4030207..4033310 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T210740 WP_001199743.1 NZ_CP080091:c4032134-4031826 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T210740 NZ_CP104603:c5219194-5218811 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT210740 WP_001118105.1 NZ_CP080091:c4032376-4032137 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT210740 NZ_CP104603:c5219436-5219194 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References