Detailed information of TA system TA021074

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 2317086..2317516
• Replicon: chromosome
• Accession: NC_006138
• Organism: Desulfotalea psychrophila LSv54

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: DP_RS18360
• Protein ID: WP_198408685.1
• Coordinates: 2317331..2317516 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: DP_RS10430
• Protein ID: WP_198408684.1
• Coordinates: 2317086..2317259 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DP_RS10415	2312182..2312865	+	684	WP_049785076.1	HNH endonuclease	-
DP_RS10420	2313536..2314618	+	1083	WP_011189275.1	DNA cytosine methyltransferase	-
DP_RS17955	2314668..2314883	+	216	WP_156792267.1	hypothetical protein	-
DP_RS18355	2315312..2316889	+	1578	WP_011189276.1	restriction endonuclease	-
DP_RS10430	2317086..2317259	+	174	WP_198408684.1	acetyltransferase	Antitoxin
DP_RS18360	2317331..2317516	+	186	WP_198408685.1	hypothetical protein	Toxin
DP_RS10445	2317945..2318727	-	783	WP_162096652.1	sel1 repeat family protein	-
DP_RS17965	2318915..2319061	-	147	WP_156792358.1	hypothetical protein	-
DP_RS10450	2319284..2320402	+	1119	WP_041277893.1	GGDEF domain-containing protein	-
DP_RS17465	2320592..2320735	-	144	WP_162096653.1	hypothetical protein	-
DP_RS10455	2320753..2321973	-	1221	WP_011189281.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-61)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6406.38 Da
• Isoelectric Point: 4.7649

>T21074 WP_198408685.1 NC_006138:2317331-2317516 [Desulfotalea psychrophila LSv54]
MKGSIDIPKLQGALARIDNAIVYSGLDDVFEIAATYTACVAVAHALPDANKRTGLAVALEY

Nucleotide

• Length: 186 bp

>T21074 NC_006138:2317331-2317516 [Desulfotalea psychrophila LSv54]
ATGAAAGGCTCTATTGACATCCCTAAACTTCAAGGCGCTTTGGCTCGTATTGACAATGCAATTGTCTACTCTGGTCTCGA
TGATGTCTTTGAAATAGCAGCAACATATACTGCATGTGTAGCTGTTGCCCACGCCCTCCCTGATGCCAACAAGCGTACAG
GCTTAGCCGTTGCCTTAGAATACTAA

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6336.77 Da
• Isoelectric Point: 11.3110

>AT21074 WP_198408684.1 NC_006138:2317086-2317259 [Desulfotalea psychrophila LSv54]
MINKKIEIYGVKAVVRPKIKALKSLNLSGGGGKQIVKSETKLVLRTHKKTFKKLADM

Nucleotide

• Length: 174 bp

>AT21074 NC_006138:2317086-2317259 [Desulfotalea psychrophila LSv54]
ATGATTAATAAAAAAATAGAAATATACGGAGTCAAAGCCGTTGTACGACCCAAGATCAAGGCACTGAAAAGCCTTAATTT
ATCAGGGGGTGGGGGTAAACAAATCGTCAAATCAGAGACGAAATTAGTTTTAAGAACACACAAAAAAACTTTCAAAAAAC
TGGCTGATATGTAA