Detailed information of TA system TA021073

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2339179..2339717
• Replicon: chromosome
• Accession: NC_006087
• Organism: Leifsonia xyli subsp. xyli str. CTCB07

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q6ACF7
• Locus tag: LXX_RS11150
• Protein ID: WP_011186917.1
• Coordinates: 2339179..2339445 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3PEG0
• Locus tag: LXX_RS11155
• Protein ID: WP_011186918.1
• Coordinates: 2339442..2339717 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXX_RS13785	2334500..2335150	-	651	WP_176714793.1	beta-propeller fold lactonase family protein	-
LXX_RS11140	2335510..2335734	+	225	WP_011186914.1	transposase	-
LXX_RS13790	2335746..2336174	+	429	WP_041768562.1	hypothetical protein	-
LXX_RS13795	2336505..2338130	-	1626	WP_011186916.1	cellulase family glycosylhydrolase	-
LXX_RS14550	2338228..2338905	-	678	WP_141692851.1	hypothetical protein	-
LXX_RS11150	2339179..2339445	-	267	WP_011186917.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LXX_RS11155	2339442..2339717	-	276	WP_011186918.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LXX_RS14955	2340286..2341544	+	1259	Protein_2272	IS21 family transposase	-
LXX_RS11165	2341541..2342350	+	810	WP_011185523.1	IS21-like element ISLxx1 family helper ATPase IstB	-
LXX_RS13815	2342413..2342610	+	198	Protein_2274	transposase	-
LXX_RS11170	2342825..2343247	+	423	WP_011185689.1	Hsp20/alpha crystallin family protein	-
LXX_RS11175	2343519..2344190	-	672	WP_050737946.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2297404..2347294	49890

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10027.54 Da
• Isoelectric Point: 10.1851

>T21073 WP_011186917.1 NC_006087:c2339445-2339179 [Leifsonia xyli subsp. xyli str. CTCB07]
VSWDVQFAPAAIRGLDRLPPRVVAAVVEFVTVTLPGNPYRMSKPLQGDLEGYYSARRGDYRVLFSLDEDRRVLLVGRIAH
RADVYRPR

Nucleotide

• Length: 267 bp

>T21073 NC_006087:c2339445-2339179 [Leifsonia xyli subsp. xyli str. CTCB07]
GTGAGCTGGGATGTTCAGTTCGCTCCGGCAGCGATCCGTGGGCTGGATCGGTTGCCGCCTCGTGTGGTCGCTGCGGTCGT
CGAGTTCGTGACGGTCACGCTGCCGGGTAACCCGTATCGGATGAGCAAGCCGCTGCAGGGCGACCTCGAAGGTTACTACT
CTGCACGCCGCGGCGACTACCGGGTGTTGTTCTCCCTCGATGAAGATCGCCGTGTGCTGTTGGTGGGACGGATTGCTCAT
CGGGCCGATGTATATCGACCGCGTTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10158.35 Da
• Isoelectric Point: 5.1548

>AT21073 WP_011186918.1 NC_006087:c2339717-2339442 [Leifsonia xyli subsp. xyli str. CTCB07]
MKTVSLSEAKDKLSRFIDEVESEHEIIQITRHGHGAAVLISQDDLDSLHETLFWLSQSGIREDLAEGRRVVESGTTVGAD
DVRARFGLPKR

Nucleotide

• Length: 276 bp

>AT21073 NC_006087:c2339717-2339442 [Leifsonia xyli subsp. xyli str. CTCB07]
ATGAAGACTGTGTCGCTGAGTGAGGCGAAGGACAAGCTCTCAAGGTTCATCGATGAGGTGGAGTCTGAGCACGAGATCAT
TCAGATCACTCGTCACGGTCACGGCGCTGCCGTTCTGATCAGCCAGGACGATTTGGATTCGCTCCATGAGACTCTGTTCT
GGCTCTCACAGTCCGGGATTCGCGAGGATCTCGCCGAGGGTCGCCGAGTCGTTGAGAGCGGTACGACTGTCGGTGCTGAT
GATGTCCGTGCGCGGTTCGGGTTGCCGAAGCGGTGA

Structures

Toxin

• AlphaFold DB: Q6ACF7

Antitoxin

• AlphaFold DB: U3PEG0