Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1865876..1866396 Replicon chromosome
Accession NC_006087
Organism Leifsonia xyli subsp. xyli str. CTCB07

Toxin (Protein)


Gene name parE Uniprot ID A0A1E2SNJ7
Locus tag LXX_RS08855 Protein ID WP_041767663.1
Coordinates 1866106..1866396 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q6ADK3
Locus tag LXX_RS08850 Protein ID WP_011186531.1
Coordinates 1865876..1866109 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXX_RS08825 1861428..1862324 - 897 WP_011186528.1 dihydropteroate synthase -
LXX_RS08830 1862327..1862512 - 186 WP_141692759.1 hypothetical protein -
LXX_RS08835 1862665..1863366 + 702 WP_011186529.1 response regulator transcription factor -
LXX_RS08840 1863406..1865121 + 1716 WP_011186530.1 HAMP domain-containing histidine kinase -
LXX_RS14395 1865190..1865747 + 558 WP_141692758.1 hypothetical protein -
LXX_RS08850 1865876..1866109 + 234 WP_011186531.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LXX_RS08855 1866106..1866396 + 291 WP_041767663.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXX_RS14400 1866584..1866664 - 81 Protein_1800 DDE-type integrase/transposase/recombinase -
LXX_RS08860 1866921..1868540 - 1620 WP_011186532.1 chaperonin GroEL -
LXX_RS08865 1868814..1869047 - 234 WP_041767664.1 cold-shock protein -
LXX_RS08870 1869204..1869752 - 549 WP_041767665.1 LytR C-terminal domain-containing protein -
LXX_RS08875 1869775..1870074 - 300 WP_011186535.1 DUF3263 domain-containing protein -
LXX_RS08880 1870248..1870667 + 420 WP_011186536.1 peptide-methionine (R)-S-oxide reductase MsrB -
LXX_RS08885 1870664..1871215 + 552 WP_011186537.1 nitroreductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11178.58 Da        Isoelectric Point: 6.7177

>T21072 WP_041767663.1 NC_006087:1866106-1866396 [Leifsonia xyli subsp. xyli str. CTCB07]
VTGYRLTPAAQRDLSSIWDFTEERWNVRQAETYVTEIRAAIERIADAPSRGRDCDEIRQGYRRYGIGSHLLFYVESTVGV
DVIRILHQRMDPTLHL

Download         Length: 291 bp

>T21072 NC_006087:1866106-1866396 [Leifsonia xyli subsp. xyli str. CTCB07]
GTGACAGGTTACCGCCTCACTCCCGCTGCGCAACGCGACCTCTCCTCGATCTGGGACTTTACCGAGGAGCGGTGGAACGT
CCGTCAGGCCGAGACCTATGTAACCGAGATCAGAGCTGCAATCGAGCGTATTGCCGACGCCCCTTCTCGTGGTCGGGACT
GTGATGAGATCCGCCAAGGGTACCGTCGGTACGGGATTGGCAGCCATCTGCTTTTCTACGTCGAGAGCACAGTCGGTGTG
GATGTGATACGGATCCTGCATCAGCGCATGGACCCGACATTGCACCTGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8356.36 Da        Isoelectric Point: 4.5026

>AT21072 WP_011186531.1 NC_006087:1865876-1866109 [Leifsonia xyli subsp. xyli str. CTCB07]
MAQNTSISLDDHFSDFLSKEVSSGRYRSASEVVRAGLRLLEDQETQLAALRAALVAGEASGMPEAFDFDAFIAMKKS

Download         Length: 234 bp

>AT21072 NC_006087:1865876-1866109 [Leifsonia xyli subsp. xyli str. CTCB07]
ATGGCTCAGAACACTTCGATCAGCCTGGATGATCACTTCTCGGACTTTCTCTCCAAAGAGGTCTCGTCAGGCCGCTATCG
GTCCGCAAGCGAGGTCGTCCGCGCCGGCCTTCGGTTGCTGGAGGACCAGGAGACGCAACTCGCAGCGCTCCGTGCCGCCC
TCGTCGCGGGTGAGGCGAGTGGCATGCCAGAGGCTTTCGACTTCGACGCTTTCATCGCGATGAAGAAGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E2SNJ7

Antitoxin

Source ID Structure
AlphaFold DB Q6ADK3

References