Detailed information of TA system TA210717

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3932087..3932700
• Replicon: chromosome
• Accession: NZ_CP080090
• Organism: Pseudomonas sp. YeP6b

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KZH41_RS17520
• Protein ID: WP_263273281.1
• Coordinates: 3932087..3932287 (+)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KZH41_RS17525
• Protein ID: WP_094952019.1
• Coordinates: 3932335..3932700 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZH41_RS17520 (KZH41_17435)	3932087..3932287	+	201	WP_263273281.1	type II toxin-antitoxin system HicA family toxin	Toxin
KZH41_RS17525 (KZH41_17440)	3932335..3932700	+	366	WP_094952019.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KZH41_RS17530 (KZH41_17445)	3932709..3933890	-	1182	WP_094952020.1	1-deoxy-D-xylulose-5-phosphate reductoisomerase	-
KZH41_RS17535 (KZH41_17450)	3934174..3935184	+	1011	WP_263273282.1	hypothetical protein	-
KZH41_RS17540 (KZH41_17455)	3935213..3937033	+	1821	WP_263273283.1	1-deoxy-D-xylulose-5-phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-65)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7457.64 Da
• Isoelectric Point: 8.7337

>T210717 WP_263273281.1 NZ_CP080090:3932087-3932287 [Pseudomonas sp. YeP6b]
VSKNEKLLAKLLNEHMAFTWPELVTLLHRLGYTQIEGAGSRVKFDIGDPSAMITLHRPHPGNELKH

Nucleotide

• Length: 201 bp

>T210717 NZ_CP104598:c3227776-3227378 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13137.86 Da
• Isoelectric Point: 6.4809

>AT210717 WP_094952019.1 NZ_CP080090:3932335-3932700 [Pseudomonas sp. YeP6b]
VNNQLKHNGYIGSIEASLEDNCLFGKVLFIKALVSYEGKTVAELDAAFREAVDDYLATCHTLGQTPEKPCKGSFNVRVGH
DLHLAAALAAARKKVTLNDLTRQALDEFLQHHSADAYPAVG

Nucleotide

• Length: 366 bp

>AT210717 NZ_CP104598:c3228003-3227776 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA