Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 4564995..4565700 Replicon chromosome
Accession NZ_CP080085
Organism Escherichia coli strain 19SZHZ869Rt

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag KZO18_RS22185 Protein ID WP_000539521.1
Coordinates 4565314..4565700 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KZO18_RS22180 Protein ID WP_001280945.1
Coordinates 4564995..4565324 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO18_RS22165 (4560159) 4560159..4561070 + 912 WP_217766171.1 glutathione ABC transporter permease GsiD -
KZO18_RS22170 (4561248) 4561248..4563589 + 2342 Protein_4333 EAL domain-containing protein -
KZO18_RS22175 (4563597) 4563597..4564925 + 1329 WP_249768716.1 GGDEF domain-containing protein -
KZO18_RS22180 (4564995) 4564995..4565324 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
KZO18_RS22185 (4565314) 4565314..4565700 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZO18_RS22190 (4565926) 4565926..4567251 - 1326 WP_137582236.1 30S ribosomal protein S12 methylthiotransferase RimO -
KZO18_RS22195 (4567464) 4567464..4567847 + 384 WP_000497137.1 biofilm formation regulator BssR -
KZO18_RS22200 (4567958) 4567958..4569073 + 1116 WP_000554946.1 aldose sugar dehydrogenase YliI -
KZO18_RS22205 (4569070) 4569070..4569696 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T210713 WP_000539521.1 NZ_CP080085:c4565700-4565314 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T210713 NZ_CP104598:c1872634-1872527 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT210713 WP_001280945.1 NZ_CP080085:c4565324-4564995 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT210713 NZ_CP104598:1872681-1872747 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References