Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1655227..1655839 Replicon chromosome
Accession NC_006086
Organism Streptococcus pyogenes MGAS10394

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag M6_RS08305 Protein ID WP_011018227.1
Coordinates 1655504..1655839 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag M6_RS08300 Protein ID WP_002988079.1
Coordinates 1655227..1655514 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6_RS08275 1650419..1651402 - 984 WP_011184964.1 tagatose-bisphosphate aldolase -
M6_RS08280 1651406..1652335 - 930 WP_011184965.1 tagatose-6-phosphate kinase -
M6_RS08285 1652381..1652896 - 516 WP_011184966.1 galactose-6-phosphate isomerase subunit LacB -
M6_RS08290 1652931..1653359 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
M6_RS08295 1653804..1654577 + 774 WP_011184967.1 DeoR/GlpR family DNA-binding transcription regulator -
M6_RS08300 1655227..1655514 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
M6_RS08305 1655504..1655839 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M6_RS10155 1655937..1656975 + 1039 Protein_1588 site-specific integrase -
M6_RS08315 1657107..1657499 - 393 WP_002982716.1 30S ribosomal protein S9 -
M6_RS08320 1657520..1657966 - 447 WP_011018228.1 50S ribosomal protein L13 -
M6_RS08325 1658184..1658390 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
M6_RS08330 1658387..1659085 - 699 WP_021340263.1 hypothetical protein -
M6_RS08335 1659221..1660081 - 861 WP_002982687.1 DegV family protein -
M6_RS08340 1660178..1660696 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T21071 WP_011018227.1 NC_006086:1655504-1655839 [Streptococcus pyogenes MGAS10394]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T21071 NC_006086:1655504-1655839 [Streptococcus pyogenes MGAS10394]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT21071 WP_002988079.1 NC_006086:1655227-1655514 [Streptococcus pyogenes MGAS10394]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT21071 NC_006086:1655227-1655514 [Streptococcus pyogenes MGAS10394]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAACAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References