Detailed information of TA system TA210708

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3613666..3615349
• Replicon: chromosome
• Accession: NZ_CP080085
• Organism: Escherichia coli strain 19SZHZ869Rt

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: KZO18_RS17555
• Protein ID: WP_087905960.1
• Coordinates: 3613666..3614583 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: KZO18_RS17560
• Protein ID: WP_024243514.1
• Coordinates: 3614576..3615349 (-)
• Length: 258 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZO18_RS17530 (3610276)	3610276..3611295	-	1020	WP_001345322.1	NADPH-dependent aldehyde reductase Ahr	-
KZO18_RS17540 (3611776)	3611776..3612417	+	642	Protein_3428	integrase arm-type DNA-binding domain-containing protein	-
KZO18_RS17545 (3612490)	3612490..3613152	+	663	WP_064186763.1	hypothetical protein	-
KZO18_RS17550 (3613205)	3613205..3613372	-	168	WP_001356018.1	hypothetical protein	-
KZO18_RS17555 (3613666)	3613666..3614583	-	918	WP_087905960.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KZO18_RS17560 (3614576)	3614576..3615349	-	774	WP_024243514.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KZO18_RS17565 (3615437)	3615437..3615765	+	329	Protein_3433	IS3 family transposase	-
KZO18_RS17570 (3615941)	3615941..3617290	-	1350	WP_096099720.1	phospholipase D-like domain-containing protein	-
KZO18_RS17575 (3617409)	3617409..3619493	-	2085	WP_001193073.1	protease Lon-related BREX system protein BrxL	-
KZO18_RS17580 (3619504)	3619504..3619932	-	429	WP_096099719.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34905.04 Da
• Isoelectric Point: 4.9230

>T210708 WP_087905960.1 NZ_CP080085:c3614583-3613666 [Escherichia coli]
MDKTSPYYRQVALLVRALPWVANESCFALKGGTAINLFIHDFPRLSVDIDLAWIPLESREVALPNVREALTRIAAELEAQ
TGIRAVLQTHNPDEMRIIVTTDDAQIKIEVSPVARGTLYPPQERDIVGAVEEEFGFAALPVVSLPDLYGGKLCAALDRQH
PRDFYDVKMLLDTQGIDRSIFNGFIAYLLSHNRPLSEVLNPRWKDITEPFQNEFSGMTFEEVSLEELKEVPERMLSALKT
HFTQQDFDFLLSFKRGEPDWNIAPEPRIQNLPAVQWKLRNIGQMSEEKRAQSLEKLKKVMTEWLR

Nucleotide

• Length: 918 bp

>T210708 NZ_CP104598:492218-492505 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTCACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 258 a.a.
• Molecular weight: 29319.73 Da
• Isoelectric Point: 9.9889

>AT210708 WP_024243514.1 NZ_CP080085:c3615349-3614576 [Escherichia coli]
MASKLNWLLQNTSPGSLVLQSWLTRNNISPSLAFKYAQNGWLIKLRAGVYARAGREPDWSDALWCLQNQLEAPVHLAGLS
SLSWQGRSHYLQLKQNQCWLSVENKAILPKWFKEFPGVEWLMVSALKLPDLDEKYRTELEVKGKRITASTPELAAYELLS
AVPQEISFEHAAELFQGLVNLNPRKVEKLLTLSQSVQTKRLYLFFASFYEHAWFKRIDTSKINLGSGNRQIVVNGKLNTQ
YQITVPENFTKKGISHG

Nucleotide

• Length: 774 bp

>AT210708 NZ_CP104598:492492-492794 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAATAAAAAATAA