Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE-RHH
Location 815945..816504 Replicon chromosome
Accession NC_005956
Organism Bartonella henselae str. Houston-1

Toxin (Protein)


Gene name relE Uniprot ID X5M706
Locus tag AYT27_RS03625 Protein ID WP_011180615.1
Coordinates 815945..816217 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID X5LVL8
Locus tag AYT27_RS03630 Protein ID WP_011180616.1
Coordinates 816214..816504 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYT27_RS03585 811270..811644 - 375 WP_011180607.1 hypothetical protein -
AYT27_RS03590 811883..812152 - 270 WP_099358259.1 hypothetical protein -
AYT27_RS03595 812378..812581 + 204 Protein_669 hypothetical protein -
AYT27_RS03600 812671..813030 + 360 WP_011180610.1 hypothetical protein -
AYT27_RS03605 813167..813646 + 480 WP_011180611.1 hypothetical protein -
AYT27_RS03610 813636..814886 + 1251 WP_011180612.1 DUF1376 domain-containing protein -
AYT27_RS03615 814870..815256 + 387 WP_082246570.1 hypothetical protein -
AYT27_RS03620 815437..815757 + 321 Protein_674 hypothetical protein -
AYT27_RS03625 815945..816217 - 273 WP_011180615.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
AYT27_RS03630 816214..816504 - 291 WP_011180616.1 hypothetical protein Antitoxin
AYT27_RS03635 816716..817162 + 447 WP_011180617.1 single-stranded DNA-binding protein -
AYT27_RS03640 817216..817749 + 534 WP_011180618.1 hypothetical protein -
AYT27_RS03645 817791..818049 + 259 Protein_679 antitoxin -
AYT27_RS03650 818049..818381 + 333 WP_011180620.1 type II toxin-antitoxin system PemK/MazF family toxin -
AYT27_RS03655 818489..818716 + 228 WP_007346764.1 ribbon-helix-helix protein, CopG family -
AYT27_RS03660 818700..818969 + 270 WP_011180622.1 type II toxin-antitoxin system RelE/ParE family toxin -
AYT27_RS03665 818999..819388 - 390 WP_011180623.1 hypothetical protein -
AYT27_RS03670 819487..819945 - 459 WP_011180624.1 hypothetical protein -
AYT27_RS03680 820244..820570 + 327 WP_011180626.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 806463..821690 15227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10747.75 Da        Isoelectric Point: 11.3976

>T21065 WP_011180615.1 NC_005956:c816217-815945 [Bartonella henselae str. Houston-1]
MKLVWTRIAHYDRQKIREYIAQENPSAALVFDKLLSKKVERLISFPNLGRVGRIRNTRELIVRKNYIMIYDVSNGTIRVL
RILHAKQKWP

Download         Length: 273 bp

>T21065 NC_005956:c816217-815945 [Bartonella henselae str. Houston-1]
ATGAAGCTCGTTTGGACACGGATAGCGCATTACGATCGTCAAAAGATACGGGAATATATCGCGCAAGAAAATCCTTCTGC
TGCATTAGTATTCGACAAGCTTTTATCTAAAAAAGTAGAAAGACTCATTAGCTTTCCTAATCTTGGTCGTGTTGGCCGAA
TTAGGAATACGCGCGAGCTTATTGTGCGTAAGAATTATATTATGATTTATGATGTTTCTAATGGCACTATACGGGTTTTG
CGCATACTTCACGCAAAACAAAAGTGGCCATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11099.43 Da        Isoelectric Point: 4.5837

>AT21065 WP_011180616.1 NC_005956:c816504-816214 [Bartonella henselae str. Houston-1]
MAETTFTFRVDDALKSEFSQAAKACDRSAAQLLRDYMRDIVKEQKEKIAHELWFQEQVQLGLNSANAGDVIPFEEIETEA
QAWRFEIQRKLKTSDS

Download         Length: 291 bp

>AT21065 NC_005956:c816504-816214 [Bartonella henselae str. Houston-1]
ATGGCTGAAACAACATTTACCTTTCGCGTTGATGATGCATTAAAAAGTGAATTTTCTCAGGCTGCAAAAGCATGTGATCG
ATCTGCTGCACAGCTCTTACGGGATTACATGCGTGATATTGTAAAAGAACAAAAAGAAAAGATAGCGCATGAATTATGGT
TTCAGGAACAAGTCCAACTTGGATTAAATTCTGCCAACGCAGGTGATGTAATACCTTTTGAAGAAATTGAAACAGAAGCA
CAAGCATGGCGCTTTGAAATACAACGCAAGCTGAAGACATCAGATTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A067W4L5

Antitoxin

Source ID Structure
AlphaFold DB A0A067W521

References