Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 407809..408340 Replicon chromosome
Accession NC_005956
Organism Bartonella henselae str. Houston-1

Toxin (Protein)


Gene name relE Uniprot ID X5M5T9
Locus tag AYT27_RS01785 Protein ID WP_011180281.1
Coordinates 408059..408340 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A0H3LWD6
Locus tag AYT27_RS01780 Protein ID WP_011180280.1
Coordinates 407809..408072 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYT27_RS01755 403955..404203 - 249 WP_011180274.1 hypothetical protein -
AYT27_RS01760 404207..406135 - 1929 WP_011180275.1 phage terminase large subunit family protein -
AYT27_RS01765 406128..406709 - 582 WP_011180276.1 hypothetical protein -
AYT27_RS01770 406772..407086 + 315 WP_011180277.1 type II toxin-antitoxin system RelE/ParE family toxin -
AYT27_RS01775 407103..407399 + 297 WP_011180278.1 HigA family addiction module antidote protein -
AYT27_RS01780 407809..408072 + 264 WP_011180280.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AYT27_RS01785 408059..408340 + 282 WP_011180281.1 type II toxin-antitoxin system YafQ family toxin Toxin
AYT27_RS01790 408383..408661 - 279 WP_011180242.1 hypothetical protein -
AYT27_RS01795 408658..409416 - 759 WP_011180282.1 phage antirepressor Ant -
AYT27_RS01800 409476..409991 - 516 WP_011180283.1 phage antirepressor Ant -
AYT27_RS01805 410284..410847 - 564 Protein_331 antA/AntB antirepressor family protein -
AYT27_RS01810 410879..411421 - 543 WP_011180285.1 phage antirepressor Ant -
AYT27_RS01825 412018..412596 - 579 WP_011180287.1 hypothetical protein -
AYT27_RS01830 412600..412920 - 321 WP_011180288.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 363045..433232 70187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11106.85 Da        Isoelectric Point: 10.3380

>T21064 WP_011180281.1 NC_005956:408059-408340 [Bartonella henselae str. Houston-1]
MRTIERTTIFKRDFKREMKGQHRHLLDTDLRKVIAALANDQPLEIRYRDHALTGNWSNYRDCHIRPDLVLIYRLIGQDRL
VLVRLGSHSQLDL

Download         Length: 282 bp

>T21064 NC_005956:408059-408340 [Bartonella henselae str. Houston-1]
ATGCGGACGATTGAACGTACGACTATCTTCAAACGTGATTTCAAGCGTGAGATGAAAGGACAACATCGGCATCTTTTAGA
TACTGATTTACGCAAAGTCATCGCAGCATTAGCAAACGATCAACCTTTAGAGATACGGTACCGTGATCATGCATTGACTG
GAAATTGGAGTAATTACCGAGATTGTCATATTCGACCTGATCTAGTGTTGATTTATCGCTTGATTGGTCAAGATAGGCTA
GTTTTAGTGCGTCTTGGTTCTCATTCACAACTTGATCTTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9565.81 Da        Isoelectric Point: 4.1403

>AT21064 WP_011180280.1 NC_005956:407809-408072 [Bartonella henselae str. Houston-1]
MATSRMVQARVPEEIQNVASQVIQASGLTVSDVVRVLMTRIAQDKAIPSVLFQPNAETIAAFAEVDEGNLKKFHSVDELF
DDLYADD

Download         Length: 264 bp

>AT21064 NC_005956:407809-408072 [Bartonella henselae str. Houston-1]
ATGGCTACCAGTCGCATGGTTCAAGCACGTGTACCGGAAGAAATTCAAAATGTCGCTAGTCAAGTTATTCAAGCTTCAGG
TTTGACAGTGAGTGATGTTGTGAGGGTATTGATGACTCGTATCGCGCAAGATAAAGCTATTCCATCTGTTTTGTTTCAAC
CCAATGCAGAAACCATAGCAGCTTTTGCTGAAGTTGATGAAGGCAACTTAAAAAAGTTTCATTCCGTAGACGAATTATTT
GATGATCTTTATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R4J6H3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LWD6

References