Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 9896..10418 Replicon plasmid p713Rt_IncX1
Accession NZ_CP080071
Organism Escherichia coli strain 19SZHZ713Rt

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag KZO15_RS22290 Protein ID WP_000220560.1
Coordinates 9896..10177 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag KZO15_RS22295 Protein ID WP_000121743.1
Coordinates 10167..10418 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO15_RS22250 (KZO15_22190) 5757..6914 - 1158 WP_000538023.1 DNA distortion polypeptide 2 -
KZO15_RS22255 (KZO15_22195) 6917..7462 - 546 WP_038976855.1 DNA distortion polypeptide 1 -
KZO15_RS22260 (KZO15_22200) 7789..8061 - 273 WP_000160399.1 hypothetical protein -
KZO15_RS22265 (KZO15_22205) 8074..8223 - 150 WP_000003880.1 hypothetical protein -
KZO15_RS22270 (KZO15_22210) 8510..8839 - 330 WP_000866648.1 hypothetical protein -
KZO15_RS22275 (KZO15_22215) 8932..9147 - 216 WP_001180116.1 hypothetical protein -
KZO15_RS22280 (KZO15_22220) 9137..9382 - 246 WP_000356546.1 hypothetical protein -
KZO15_RS22285 (KZO15_22225) 9427..9750 - 324 WP_001181903.1 hypothetical protein -
KZO15_RS22290 (KZO15_22230) 9896..10177 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZO15_RS22295 (KZO15_22235) 10167..10418 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
KZO15_RS22300 (KZO15_22240) 11674..12510 + 837 WP_001050931.1 RepB family plasmid replication initiator protein -
KZO15_RS22305 (KZO15_22245) 12550..12996 + 447 WP_001074386.1 hypothetical protein -
KZO15_RS22310 (KZO15_22250) 13133..13486 + 354 WP_000876434.1 DNA distortion polypeptide 3 -
KZO15_RS22315 (KZO15_22255) 13546..14514 - 969 WP_166501310.1 IS5-like element IS903B family transposase -
KZO15_RS22320 (KZO15_22260) 14516..14809 - 294 WP_015060510.1 hypothetical protein -
KZO15_RS22325 (KZO15_22265) 14825..15055 - 231 WP_000051064.1 plasmid partition protein ParG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..16714 16714
- flank IS/Tn - - 13546..14469 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T210636 WP_000220560.1 NZ_CP080071:c10177-9896 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T210636 NZ_CP104582:1283059-1283628 [Pseudomonas sp. GD03919]
ATGTTCAAGCCACAGTTGGTGACGTTGCAGCGTGGCGCTCTGCGCCTGGAACCCATGGCCGACGCTGACATTCCGGCGTT
GGTCGCCTTGGCCGAAGCCAATCGTGAGGCGTTGTTGTACATGAGCGGCACGCAGCGACTGGACTGGTATCGCAGCGCCC
TGGCCGACTTGCGCGAGCAGCGGGCCTTGCCTTTCGTCATTCGCCTGGGTGACGAACTGGTCGGAACCACTCGTTTCGCT
GATTTCATGAACAGCCTGCCCGCCTGCGAAATCGGCTGGACCTGGCTCGATCGTCATCAACATGGCAGCGGCCTGAATAC
CAGTATCAAGTACCTGATGCTCAGGCATGCCTTCGATCATTGGGGCATGGTTCGCGTGCAACTGAAAACCGCCGCCAGCA
ACCTGCGCGCGCAGCGCGCCATCGAGAAACTGGGTGCGGTACGCGAGGGGCTGCTGCGCAACCATCGCCGTCTGGCTGAT
GGCCGTCTCGACGATAGCGTGCTGTTCAGCATCACCGACCACGAGTGGCCGGCGCTGCGCGAGGCGATGGAGGCAGGCTT
CGGCGCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT210636 WP_000121743.1 NZ_CP080071:c10418-10167 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT210636 NZ_CP104582:1283634-1284461 [Pseudomonas sp. GD03919]
ATGCAGACCCGCGAGCAGACCCGCTTCTGGCAAGCCTCCGCCTTGAGCGGAGTCGAGCTGTTGCAGGCGCGCTACCTCGA
GCAGCGTTTCGCTCCGCACGTACATGAAGGGTTCGTCTTCACCGTGATCGAGCATGGCGCCCAGCGCTTTCGCCACCGTG
GCTGCGATCATCTGGCGCCGCAGGGCAGTATGGTGCTGATCAACCCGGACGAAGTGCACACCGGCTCCAAGGCGCACGAA
GACGGCTGGCGCTATCGCGGTTTCTATCCCGACAACGCCCAGGTACTGGGAGCGCTGCAGGAACTGGGCCTGGCCAAGGC
CGGCATGCCGTCGTTTACCTTCAGCGTGCTGCATGATCCACGTTTGCATGCGGCCTTTCTGCAACTGCACCAACTGCTCG
AGGGTGGTGCTGAGGCGCTGCAGCAGCAACTGGCCTGGCGTGAGGCGATTCTGCTGCTGTTTCAGCACCATGCGCAGCTT
GCCGAACCACCTGCGCCTGGGCGTGAGCCCTGGGCAGTGGCTTGTGCCAAGCAGATGCTCGCCGAGCGGCTGATCGAGCC
GCCCTCGCTGGAGGAACTGGCGGCTGCGGTCAACCTCTCACCTTTTCACTTCGCGCGCGTATTTCGCCGCGCGACCGGCT
TGCCGCCGCATGCCTGGCTCAAACAGCGTCGCCTGGAGCAGGCGCGGGCATTGCTAAAGACGGGTTGCACGGCGGTCGCT
GTGGCGATGCAGTTGGGCTTCGCCGATCAGAGTCACTTGTCGCGACAGTTCAAGCAGGTTTATGGCGTGAGCCCTGGCGA
ATATCGCAGCGCGGTGGCCCGGAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References