Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4197170..4197667 Replicon chromosome
Accession NZ_CP080070
Organism Escherichia coli strain 19SZHZ713Rt

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag KZO15_RS20035 Protein ID WP_001173343.1
Coordinates 4197170..4197343 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag KZO15_RS20040 Protein ID WP_000398619.1
Coordinates 4197371..4197667 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO15_RS20025 (4193840) 4193840..4195297 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
KZO15_RS20030 (4195534) 4195534..4197051 + 1518 WP_001295074.1 lysine--tRNA ligase -
KZO15_RS20035 (4197170) 4197170..4197343 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
KZO15_RS20040 (4197371) 4197371..4197667 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
KZO15_RS20045 (4197894) 4197894..4198166 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
KZO15_RS20050 (4198178) 4198178..4198408 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
KZO15_RS20055 (4198589) 4198589..4200220 + 1632 WP_001216477.1 sensor histidine kinase -
KZO15_RS20060 (4200217) 4200217..4200936 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T210635 WP_001173343.1 NZ_CP080070:c4197343-4197170 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T210635 NZ_CP104582:c640048-639704 [Pseudomonas sp. GD03919]
ATGAAAGCACTATTTGTCGAACTACCGCCCTTTGAGCGCCATAGAGCGGACTACCTGGACGATGAGGCCTTTCGTAGCTT
CCAGCGCCTGCTGATGAAGAACCCGGAAGCCGGCGACGTGATCCAGGGAACCGGCGGCCTACGAAAGATTCGCTTCGCCG
ACGAGCGACGACAGAAAGGCAAGCGCGGCGGCATCCGAGTCATCTACTACTGGTGGCTGGGTGGCGCGCAGTTCTGGCTG
TTTACCCTGTATGGGAAGGACGTCCAGGACGACCTGAACGAGCAGCAGAAGAAATTACTCAAGCAGCTGCTGCAAGCAGA
AATTGATGCGAGGACGACATCATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT210635 WP_000398619.1 NZ_CP080070:c4197667-4197371 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT210635 NZ_CP104582:c639707-639393 [Pseudomonas sp. GD03919]
ATGAAACGAGACATCTTTGCCGAGCTGGTCGAGGGCTTCGAGGCTTTGGAGGATGAACGCCAAGGCAAGGTGACTCTGCG
CTCGCACAAAGTCCAATTGCCCGAACTGTGCGAAGTCAGCTCCGAGGAGCTGGTGGAGATCCGCCAGAAGCTGAACATGT
CACGCCCGGTTTTCGCCATGTATCTGCGCACCAACCCGCGCACCTTGGAGAACTGGGAACAAGGCCGAGCCAAGCCAAAC
GCCCAGGCGACTACGCTGATTCGTCTGGTGCAAAAGTATCCTGAAACTGTCGAGCACCTTGCAGCCCTTGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References