Detailed information of TA system TA210634

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4020056..4020891
• Replicon: chromosome
• Accession: NZ_CP080070
• Organism: Escherichia coli strain 19SZHZ713Rt

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LDL9
• Locus tag: KZO15_RS19160
• Protein ID: WP_001094444.1
• Coordinates: 4020056..4020433 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7LDN9
• Locus tag: KZO15_RS19165
• Protein ID: WP_001285607.1
• Coordinates: 4020523..4020891 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZO15_RS19135 (4015558)	4015558..4015737	+	180	Protein_3763	peptidase	-
KZO15_RS19140 (4016136)	4016136..4018170	-	2035	Protein_3764	hypothetical protein	-
KZO15_RS19145 (4019126)	4019126..4019269	-	144	Protein_3765	hypothetical protein	-
KZO15_RS19150 (4019354)	4019354..4019551	-	198	WP_001327226.1	DUF957 domain-containing protein	-
KZO15_RS19155 (4019571)	4019571..4020059	-	489	WP_000761685.1	DUF5983 family protein	-
KZO15_RS19160 (4020056)	4020056..4020433	-	378	WP_001094444.1	TA system toxin CbtA family protein	Toxin
KZO15_RS19165 (4020523)	4020523..4020891	-	369	WP_001285607.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KZO15_RS19170 (4020971)	4020971..4021192	-	222	WP_000692350.1	DUF987 domain-containing protein	-
KZO15_RS19175 (4021279)	4021279..4021755	-	477	WP_001384029.1	RadC family protein	-
KZO15_RS19180 (4021770)	4021770..4022255	-	486	WP_000213722.1	antirestriction protein	-
KZO15_RS19185 (4022347)	4022347..4023165	-	819	WP_001175175.1	DUF932 domain-containing protein	-
KZO15_RS19190 (4023255)	4023255..4023464	-	210	WP_032150870.1	DUF905 family protein	-
KZO15_RS19195 (4023494)	4023494..4024171	-	678	WP_166488803.1	hypothetical protein	-
KZO15_RS19200 (4024290)	4024290..4025174	-	885	WP_053291272.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4009555..4051983	42428

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14087.02 Da
• Isoelectric Point: 7.3523

>T210634 WP_001094444.1 NZ_CP080070:c4020433-4020056 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Nucleotide

• Length: 378 bp

>T210634 NZ_CP104582:c441626-441345 [Pseudomonas sp. GD03919]
GTGAAGCTGGCCTGGACGCGCCTTGCGCTGAACGACCGCCAAGCCATCCGCAGTTATATCGCTCAGGACAATCCCATTGC
CGCCCTGGCGCTGGATGAGTTATTCGCAGAAAAGGCCGGCCGTCTGGCCGATCACCCCGGCCTGGGGCGACCAGGCCGGG
TGAACGGTACACGCGAACTGGTTGTTCATCAGCATTACCTGATGATCTACGACCTGGCCAATGATCAGGTACGGATACTG
CGCGTGCTGCATACAGCGCGTCAGTGGCCCAGTGCGGACTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13689.53 Da
• Isoelectric Point: 6.4669

>AT210634 WP_001285607.1 NZ_CP080070:c4020891-4020523 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT210634 NZ_CP104582:c441913-441623 [Pseudomonas sp. GD03919]
ATGAGTGAAGCCACCTTTACCTTTCGCGTGGACGACGCCCTGAAAAGCGAATTTGCCCAGGCTGCCAAAGCCCGCGACCG
CACTGGCGCGCAGTTGCTGCGCGACTTCATGCGTGATTTCGTCCGACAGCAGCAGGAGGCCGCCGAGCACGATGTCTGGC
TGCGCCGCCAGGTACAGATGGGGCTGGATTCGGCCAATGCTGGTGAGTTGCTCAGTGGCGAAGAGGTCGAAGCCGAAGCC
GCCGCATGGCGTGCTGAAATGCGCCGCAAGCTGGACAGCGCCGCGTCGTGA

Structures

Toxin

• AlphaFold DB: B1LDL9

Antitoxin

• AlphaFold DB: A0A1M0JLU8