Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49191..50026 Replicon chromosome
Accession NZ_CP080070
Organism Escherichia coli strain 19SZHZ713Rt

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2Y0VZS4
Locus tag KZO15_RS00255 Protein ID WP_032304079.1
Coordinates 49191..49568 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A369FMF5
Locus tag KZO15_RS00260 Protein ID WP_024188924.1
Coordinates 49658..50026 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZO15_RS00225 (44556) 44556..45479 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
KZO15_RS00230 (45590) 45590..46774 - 1185 WP_001172876.1 sugar efflux transporter -
KZO15_RS00235 (47171) 47171..47332 - 162 Protein_46 RhuM family protein -
KZO15_RS00240 (47567) 47567..48412 - 846 WP_000065752.1 DUF4942 domain-containing protein -
KZO15_RS00245 (48497) 48497..48694 - 198 WP_000839243.1 DUF957 domain-containing protein -
KZO15_RS00250 (48706) 48706..49194 - 489 WP_000761714.1 DUF5983 family protein -
KZO15_RS00255 (49191) 49191..49568 - 378 WP_032304079.1 TA system toxin CbtA family protein Toxin
KZO15_RS00260 (49658) 49658..50026 - 369 WP_024188924.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KZO15_RS00265 (50100) 50100..50321 - 222 WP_073544043.1 DUF987 domain-containing protein -
KZO15_RS00270 (50390) 50390..50866 - 477 WP_001186725.1 RadC family protein -
KZO15_RS00275 (50882) 50882..51367 - 486 WP_157700654.1 antirestriction protein -
KZO15_RS00280 (51459) 51459..52277 - 819 WP_157700655.1 DUF932 domain-containing protein -
KZO15_RS00285 (52395) 52395..52590 - 196 Protein_56 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14102.08 Da        Isoelectric Point: 7.9094

>T210617 WP_032304079.1 NZ_CP080070:c49568-49191 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T210617 NZ_CP104579:c3384325-3383573 [Pseudomonas oleovorans]
ATGGATATCTGGCAACTATGCGACGGCGAGCGACAGGTGCGACCGCTGCGCGGCAAGCTGTTGCGCATGGTGGAGAGCCA
GGCCCAGGTTGCGACCCTGCAACTGGTGGATAACCTGGCCGAGCAGACCCTGCTCGAGGAACTGCTCGAGAGCAGCAAGC
CGCCGCTGCCTGAAGCCGCCGAGCCGTTGCACTACCTGCTGAAGACGCCGTTTCGTTATCCGCCGCTGCGTTGGGGCTCG
CGCTTCGGCCGCGTGCACGAACCCAGCCTGTTCTACGCCGCTCAGCGTCTGCAAACGGCGATGGCCGAGGCCGCCTACTA
CCGTTTCGTATTGTGGAATGGCATGGTCGTGCCGCCGCCCAGTGGCCGCATCCTCTCCGAGCATTCGACCTTCGAGGCGC
GTTACCGCGTCGAGCACGGTATCCAGTTGCAACAGTCGCCTTTCGCTCAACATGACGCACTGTTGGCTCACCCCAGTGAT
TACAGCGTGCCTCGGCGTCTCGGTACGTCGATGCGCGCGGCGGGCATTCAGGCTTTCGAGTACCGCTCGGCACGCTGTCC
TGACGGTGGCAGCAATGTGGCGCTCTACGTGCCGGCTGCGTTCGTGGAGAAGCGTCCGCGTAATCTGACGGCCTGGTTGT
GTGAAACCACGAGCGAGTACGTGGCGTTCAAGCATGCGCAAACGCCGGATCAACCACGGCTGTTTCACTGGGAGCAGTTT
CTGGTGCAGGGGCAATTGCCGCACCCCGCGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13633.45 Da        Isoelectric Point: 6.7386

>AT210617 WP_024188924.1 NZ_CP080070:c50026-49658 [Escherichia coli]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADTYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKT

Download         Length: 369 bp

>AT210617 NZ_CP104579:c3384780-3384409 [Pseudomonas oleovorans]
ATGAGTGCTGTGACTCGCTCTCAGCCCGATGCCGATGCGGTACTGGCTAAAGCCCTGCTCAATACCCGTGAGCAACTGGG
GCTGACGCAGCAGGAGCTGGCCGACATCGTTGGCGTCCATCGCAGTGCCATCAGCCGCTGGAGTGAGCAGGGTGGTTTGC
GTCCGCAGAGCAAGACCGGCGAGCTGGCGCTGTTGCTGATACGCGCCTATCGCGCGCTGTTTGCCCTGTTTGGCGGCAAT
CAGCAGGACATGCGCCATTTTCTGCGCACCGAAAATCGCCATCTGGCAGGTATTCCGCTGCAGCAGATGAGTCAGGTGCA
GGGGCTGGTGCGTGTTGTCGAGTATCTGGACGCCATTCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Y0VZS4

Antitoxin

Source ID Structure
AlphaFold DB A0A369FMF5

References